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SMILES: C[C@H]1CCc2c(Br)c(F)c(Br)cc2N1C=S

InChI Key: InChIKey=HRJAGBWLKOKNPD-LURJTMIESA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50280397   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Rap guanine nucleotide exchange factor 3


(Homo sapiens (Human))		BDBM50280397
PNG
(CHEMBL4175985)
Show SMILES C[C@H]1CCc2c(Br)c(F)c(Br)cc2N1C=S |r|
Show InChI InChI=1S/C11H10Br2FNS/c1-6-2-3-7-9(15(6)5-16)4-8(12)11(14)10(7)13/h4-6H,2-3H2,1H3/t6-/m0/s1
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Similars
Article
PubMed
n/an/a>1.00E+5n/an/an/an/an/an/a



Institute for Research in Cancer and Allied Diseases

Curated by ChEMBL


Assay Description
Inhibition of recombinant human GST-tagged EPAC1 (149 to 881 residues) expressed in Escherichia coli Rosetta 2(DE3) assessed as reduction in guanine ...

ACS Med Chem Lett 8: 1183-1187 (2017)


Article DOI: 10.1021/acsmedchemlett.7b00358
BindingDB Entry DOI: 10.7270/Q20C4Z83
More data for this
Ligand-Target Pair