BDBM50280810 5-{2-[4-(4-Fluoro-benzyl)-piperidin-1-yl]-1-hydroxy-ethyl}-1,3-dihydro-indol-2-one::CHEMBL173092

SMILES: OC(CN1CCC(Cc2ccc(F)cc2)CC1)c1ccc2NC(=O)Cc2c1

InChI Key: InChIKey=JZAYUGIZPPLLGT-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50280810   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor (Rattus norvegicus (rat)-Rattus norvegicus (Rat))	BDBM50280810 (5-{2-[4-(4-Fluoro-benzyl)-piperidin-1-yl]-1-hydrox...) Show SMILES OC(CN1CCC(Cc2ccc(F)cc2)CC1)c1ccc2NC(=O)Cc2c1 Show InChI InChI=1S/C22H25FN2O2/c23-19-4-1-15(2-5-19)11-16-7-9-25(10-8-16)14-21(26)17-3-6-20-18(12-17)13-22(27)24-20/h1-6,12,16,21,26H,7-11,13-14H2,(H,24,27)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article	n/a	n/a	183	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Tested for the Alpha-1 adrenergic receptor affinity in a standard radioligand binding assay with [3H]- prazosin				Bioorg Med Chem Lett 3: 91-94 (1993) Article DOI: 10.1016/S0960-894X(00)80098-0 BindingDB Entry DOI: 10.7270/Q2GT5N4S
					More data for this Ligand-Target Pair
NMDA receptor subunit 2C (GluN2C) (Rattus norvegicus (Rat))	BDBM50280810 (5-{2-[4-(4-Fluoro-benzyl)-piperidin-1-yl]-1-hydrox...) Show SMILES OC(CN1CCC(Cc2ccc(F)cc2)CC1)c1ccc2NC(=O)Cc2c1 Show InChI InChI=1S/C22H25FN2O2/c23-19-4-1-15(2-5-19)11-16-7-9-25(10-8-16)14-21(26)17-3-6-20-18(12-17)13-22(27)24-20/h1-6,12,16,21,26H,7-11,13-14H2,(H,24,27)	UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article	n/a	n/a	600	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Tested for the NMDA antagonist activity using a functional assay, by protection of cultured hippocampus neurons from the toxic effects of extracellul...				Bioorg Med Chem Lett 3: 91-94 (1993) Article DOI: 10.1016/S0960-894X(00)80098-0 BindingDB Entry DOI: 10.7270/Q2GT5N4S
					More data for this Ligand-Target Pair