BDBM50283757 (S)-2-{2-[3-((R)-2-Amino-3-mercapto-propylamino)-phenyl]-acetylamino}-4-methylsulfanyl-butyric acid::CHEMBL433417
SMILES: CSCC[C@H](NC(=O)Cc1cccc(NC[C@@H](N)CS)c1)C(O)=O
InChI Key: InChIKey=DYODOZKNLWDKGU-OCCSQVGLSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 2 hits for monomerid = 50283757 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Geranylgeranyl transferase type I beta subunit/Protein Farnesyltransferase (PFT)
(Homo sapiens (Human)) | BDBM50283757
((S)-2-{2-[3-((R)-2-Amino-3-mercapto-propylamino)-p...)Show SMILES CSCC[C@H](NC(=O)Cc1cccc(NC[C@@H](N)CS)c1)C(O)=O Show InChI InChI=1S/C16H25N3O3S2/c1-24-6-5-14(16(21)22)19-15(20)8-11-3-2-4-13(7-11)18-9-12(17)10-23/h2-4,7,12,14,18,23H,5-6,8-10,17H2,1H3,(H,19,20)(H,21,22)/t12-,14+/m1/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article
| n/a | n/a | 9.74E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibitory activity against geranylgeranyl transferase |
Bioorg Med Chem Lett 4: 2775-2780 (1994)
Article DOI: 10.1016/S0960-894X(01)80593-X BindingDB Entry DOI: 10.7270/Q21J99Q0 |
More data for this Ligand-Target Pair | |
Protein Farnesyltransferase (PFT)
(Homo sapiens (Human)) | BDBM50283757
((S)-2-{2-[3-((R)-2-Amino-3-mercapto-propylamino)-p...)Show SMILES CSCC[C@H](NC(=O)Cc1cccc(NC[C@@H](N)CS)c1)C(O)=O Show InChI InChI=1S/C16H25N3O3S2/c1-24-6-5-14(16(21)22)19-15(20)8-11-3-2-4-13(7-11)18-9-12(17)10-23/h2-4,7,12,14,18,23H,5-6,8-10,17H2,1H3,(H,19,20)(H,21,22)/t12-,14+/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article
| n/a | n/a | 240 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition of farnesyl transferase |
Bioorg Med Chem Lett 4: 2775-2780 (1994)
Article DOI: 10.1016/S0960-894X(01)80593-X BindingDB Entry DOI: 10.7270/Q21J99Q0 |
More data for this Ligand-Target Pair | |