BDBM50284487 (1Z)-N'-cyano-2-{4-[4-(4-fluorophenyl)-5-pyridin-4-yl-1H-imidazol-2-yl]phenyl}ethanimidamide::CHEMBL17148

SMILES: NC(Cc1ccc(cc1)-c1nc(c([nH]1)-c1ccc(F)cc1)-c1ccncc1)=NC#N

InChI Key: InChIKey=NSYZFNNALDBTTO-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50284487   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Arachidonate 5-lipoxygenase (Homo sapiens (Human))	BDBM50284487 ((1Z)-N'-cyano-2-{4-[4-(4-fluorophenyl)-5-pyridin-4...) Show SMILES NC(Cc1ccc(cc1)-c1nc(c([nH]1)-c1ccc(F)cc1)-c1ccncc1)=NC#N |w:27.31| Show InChI InChI=1S/C23H17FN6/c24-19-7-5-16(6-8-19)21-22(17-9-11-27-12-10-17)30-23(29-21)18-3-1-15(2-4-18)13-20(26)28-14-25/h1-12H,13H2,(H2,26,28)(H,29,30)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article	n/a	n/a	420	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibitory activity against interleukin-1(IL-1) synthesis, using intact human monocytes				Bioorg Med Chem Lett 5: 1171-1176 (1995) Article DOI: 10.1016/0960-894X(95)00189-Z BindingDB Entry DOI: 10.7270/Q28S4PV1
					More data for this Ligand-Target Pair
Arachidonate 5-lipoxygenase (Rattus norvegicus)	BDBM50284487 ((1Z)-N'-cyano-2-{4-[4-(4-fluorophenyl)-5-pyridin-4...) Show SMILES NC(Cc1ccc(cc1)-c1nc(c([nH]1)-c1ccc(F)cc1)-c1ccncc1)=NC#N |w:27.31| Show InChI InChI=1S/C23H17FN6/c24-19-7-5-16(6-8-19)21-22(17-9-11-27-12-10-17)30-23(29-21)18-3-1-15(2-4-18)13-20(26)28-14-25/h1-12H,13H2,(H2,26,28)(H,29,30)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article	n/a	n/a	3.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibitory activity against 5-lipoxygenase enzyme from RBL-1 cells				Bioorg Med Chem Lett 5: 1171-1176 (1995) Article DOI: 10.1016/0960-894X(95)00189-Z BindingDB Entry DOI: 10.7270/Q28S4PV1
					More data for this Ligand-Target Pair