BDBM50287068 CHEMBL4172576::US10759787, Example 30
SMILES: CCN(C1CCOCC1)c1cc2oc(cc2c(C(=O)NCc2c(OC)cc(C)[nH]c2=O)c1C)C#N
InChI Key: InChIKey=GWWPLMJVLCHYQG-UHFFFAOYSA-N
Data: 2 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Histone-lysine N-methyltransferase EZH2 (A677G) (Homo sapiens (Human)) | BDBM50287068![]() (CHEMBL4172576 | US10759787, Example 30) | PDB GoogleScholar AffyNet ![]() | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 0.800 | n/a | n/a | n/a | n/a | n/a | n/a |
Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd. US Patent | Assay Description The activity of EZH2 enzyme (with A677G mutant or Y641F mutant) was tested by the following method.The method was used to determine the inhibitory ef... | US Patent US10759787 (2020) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
EZH1/PRC2 (Homo sapiens (Human)) | BDBM50287068![]() (CHEMBL4172576 | US10759787, Example 30) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 0.800 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Hengrui Pharmaceutical Co. Ltd. Curated by ChEMBL | Assay Description Inhibition of human N-terminal His-tagged EZH2/flag-tagged EED/SUZ12/AEBP2/RBAP48 A677G mutant (2 to end residues) expressed in baculovirus infected ... | ACS Med Chem Lett 9: 98-102 (2018) Article DOI: 10.1021/acsmedchemlett.7b00437 BindingDB Entry DOI: 10.7270/Q2ZS3028 | |||||||||||
More data for this Ligand-Target Pair |