BDBM50290959 CHEMBL96931::N-{2-Benzo[1,3]dioxol-5-yl-2-[3-(2,5-dimethoxy-phenyl)-6-oxo-5,6-dihydro-4H-pyridazin-1-yl]-acetyl}-4-isopropyl-benzenesulfonamide

SMILES: COc1ccc(OC)c(c1)C1=NN(C(C(=O)NS(=O)(=O)c2ccc(cc2)C(C)C)c2ccc3OCOc3c2)C(=O)CC1

InChI Key: InChIKey=JNESLWRACVNCNX-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50290959   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
EDNRA (RAT)	BDBM50290959 (CHEMBL96931 | N-{2-Benzo[1,3]dioxol-5-yl-2-[3-(2,5...) Show SMILES COc1ccc(OC)c(c1)C1=NN(C(C(=O)NS(=O)(=O)c2ccc(cc2)C(C)C)c2ccc3OCOc3c2)C(=O)CC1 |t:11| Show InChI InChI=1S/C30H31N3O8S/c1-18(2)19-5-9-22(10-6-19)42(36,37)32-30(35)29(20-7-12-26-27(15-20)41-17-40-26)33-28(34)14-11-24(31-33)23-16-21(38-3)8-13-25(23)39-4/h5-10,12-13,15-16,18,29H,11,14,17H2,1-4H3,(H,32,35)	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of specific binding of [125I]-ET-1 (endothelin 1) to the endothelin A receptor of rat aorta membranes				Bioorg Med Chem Lett 7: 275-280 (1997) Article DOI: 10.1016/S0960-894X(96)00617-8 BindingDB Entry DOI: 10.7270/Q2QF8SWT
					More data for this Ligand-Target Pair
Endothelin receptor ET-B (Sus scrofa)	BDBM50290959 (CHEMBL96931 | N-{2-Benzo[1,3]dioxol-5-yl-2-[3-(2,5...) Show SMILES COc1ccc(OC)c(c1)C1=NN(C(C(=O)NS(=O)(=O)c2ccc(cc2)C(C)C)c2ccc3OCOc3c2)C(=O)CC1 |t:11| Show InChI InChI=1S/C30H31N3O8S/c1-18(2)19-5-9-22(10-6-19)42(36,37)32-30(35)29(20-7-12-26-27(15-20)41-17-40-26)33-28(34)14-11-24(31-33)23-16-21(38-3)8-13-25(23)39-4/h5-10,12-13,15-16,18,29H,11,14,17H2,1-4H3,(H,32,35)	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of specific binding of [125I]-ET-1 (endothelin 1) to endothelin B receptor of porcine kidney membranes				Bioorg Med Chem Lett 7: 275-280 (1997) Article DOI: 10.1016/S0960-894X(96)00617-8 BindingDB Entry DOI: 10.7270/Q2QF8SWT
					More data for this Ligand-Target Pair