BDBM50292990 2-amino-4-methyl-5-oxo-7-phenyl-5,6,7,8-tetrahydro-4H-chromene-3-carbonitrile::CHEMBL474063

SMILES: CC1C(C#N)C(=N)OC2=C1C(=O)CC(C2)c1ccccc1

InChI Key: InChIKey=HWTAGBXLIQKWLS-UHFFFAOYSA-N

Data: 5 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50292990   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Excitatory amino acid transporter 1 (Homo sapiens (Human))	BDBM50292990 (2-amino-4-methyl-5-oxo-7-phenyl-5,6,7,8-tetrahydro...) Show SMILES CC1C(C#N)C(=N)OC2=C1C(=O)CC(C2)c1ccccc1 |c:8| Show InChI InChI=1S/C17H16N2O2/c1-10-13(9-18)17(19)21-15-8-12(7-14(20)16(10)15)11-5-3-2-4-6-11/h2-6,10,12-13,19H,7-8H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	9.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Copenhagen Curated by ChEMBL					Assay Description Displacement of [3H]D-Asp from human EAAT1 receptor expressed in HEK293 cells				J Med Chem 52: 912-5 (2009) Article DOI: 10.1021/jm8013458 BindingDB Entry DOI: 10.7270/Q2PV6KCP
					More data for this Ligand-Target Pair
Excitatory amino acid transporter 2 (Homo sapiens (Human))	BDBM50292990 (2-amino-4-methyl-5-oxo-7-phenyl-5,6,7,8-tetrahydro...) Show SMILES CC1C(C#N)C(=N)OC2=C1C(=O)CC(C2)c1ccccc1 |c:8| Show InChI InChI=1S/C17H16N2O2/c1-10-13(9-18)17(19)21-15-8-12(7-14(20)16(10)15)11-5-3-2-4-6-11/h2-6,10,12-13,19H,7-8H2,1H3	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>3.16E+5	n/a	n/a	n/a	n/a	n/a	n/a
University of Copenhagen Curated by ChEMBL					Assay Description Displacement of [3H]D-Asp from human EAAT2 receptor expressed in HEK293 cells				J Med Chem 52: 912-5 (2009) Article DOI: 10.1021/jm8013458 BindingDB Entry DOI: 10.7270/Q2PV6KCP
					More data for this Ligand-Target Pair
Excitatory amino acid transporter 1 (Homo sapiens (Human))	BDBM50292990 (2-amino-4-methyl-5-oxo-7-phenyl-5,6,7,8-tetrahydro...) Show SMILES CC1C(C#N)C(=N)OC2=C1C(=O)CC(C2)c1ccccc1 |c:8| Show InChI InChI=1S/C17H16N2O2/c1-10-13(9-18)17(19)21-15-8-12(7-14(20)16(10)15)11-5-3-2-4-6-11/h2-6,10,12-13,19H,7-8H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	9.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Copenhagen Curated by ChEMBL					Assay Description Inhibition of human EAAT1 expressed in HEK293 cells assessed as inhibition of 3[H]-D-Aspartate uptake after 6 mins by scintillation counting method				J Med Chem 55: 5403-12 (2012) Article DOI: 10.1021/jm300345z BindingDB Entry DOI: 10.7270/Q2Q81F5W
					More data for this Ligand-Target Pair
Excitatory amino acid transporter 1 (Homo sapiens (Human))	BDBM50292990 (2-amino-4-methyl-5-oxo-7-phenyl-5,6,7,8-tetrahydro...) Show SMILES CC1C(C#N)C(=N)OC2=C1C(=O)CC(C2)c1ccccc1 |c:8| Show InChI InChI=1S/C17H16N2O2/c1-10-13(9-18)17(19)21-15-8-12(7-14(20)16(10)15)11-5-3-2-4-6-11/h2-6,10,12-13,19H,7-8H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	9.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Copenhagen Curated by ChEMBL					Assay Description Inhibition of human EAAT1 expressed in HEK293 cells by [3H]D-Asp uptake assay				J Med Chem 53: 7180-91 (2010) Article DOI: 10.1021/jm1009154 BindingDB Entry DOI: 10.7270/Q2VM4CGX
					More data for this Ligand-Target Pair
Excitatory amino acid transporter 3 (Homo sapiens (Human))	BDBM50292990 (2-amino-4-methyl-5-oxo-7-phenyl-5,6,7,8-tetrahydro...) Show SMILES CC1C(C#N)C(=N)OC2=C1C(=O)CC(C2)c1ccccc1 |c:8| Show InChI InChI=1S/C17H16N2O2/c1-10-13(9-18)17(19)21-15-8-12(7-14(20)16(10)15)11-5-3-2-4-6-11/h2-6,10,12-13,19H,7-8H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>3.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
University of Copenhagen Curated by ChEMBL					Assay Description Displacement of [3H]D-Asp from human EAAT3 receptor expressed in HEK293 cells				J Med Chem 52: 912-5 (2009) Article DOI: 10.1021/jm8013458 BindingDB Entry DOI: 10.7270/Q2PV6KCP
					More data for this Ligand-Target Pair