BDBM50295296 CHEMBL539470::cis-3-((1R,2S)-2-((dimethylamino)methyl)cyclopentyl)-1H-indole-5-carbonitrile
SMILES: CN(C)C[C@H]1CCC[C@H]1c1c[nH]c2ccc(cc12)C#N
InChI Key: InChIKey=RXJIAQGHWRMBEZ-ZIAGYGMSSA-N
Data: 2 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sodium-dependent serotonin transporter (Homo sapiens (Human)) | BDBM50295296 (CHEMBL539470 | cis-3-((1R,2S)-2-((dimethylamino)me...) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development Curated by ChEMBL | Assay Description Displacement of [3H]citalopram from human SERT expressed in HEK293 cell membranes | Bioorg Med Chem Lett 23: 2948-50 (2013) Article DOI: 10.1016/j.bmcl.2013.03.045 BindingDB Entry DOI: 10.7270/Q2BC42G4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium-dependent serotonin transporter (Homo sapiens (Human)) | BDBM50295296 (CHEMBL539470 | cis-3-((1R,2S)-2-((dimethylamino)me...) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 130 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers SquibbPharmaceutical Research Institute Curated by ChEMBL | Assay Description Displacement of [125I]RTI-55 from human SERT expressed in HEK293 cells | Bioorg Med Chem Lett 19: 4031-3 (2009) Article DOI: 10.1016/j.bmcl.2009.06.026 BindingDB Entry DOI: 10.7270/Q2Q81D3K | |||||||||||
More data for this Ligand-Target Pair |