BindingDB PrimarySearch

BDBM50295549 4-(3-(pyridin-2-yl)-1,2,4-oxadiazol-5-yl)-N-(4-(trifluoromethyl)phenyl)piperidine-1-carboxamide::CHEMBL555347

SMILES: FC(F)(F)c1ccc(NC(=O)N2CCC(CC2)c2nc(no2)-c2ccccn2)cc1

InChI Key: InChIKey=FOJGGWIJRFOXIF-UHFFFAOYSA-N

Data: 9 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50295549
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
EBifunctional epoxide hydrolase 2 (Homo sapiens (Human))	BDBM50295549 (4-(3-(pyridin-2-yl)-1,2,4-oxadiazol-5-yl)-N-(4-(tr...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of human sEH				J Med Chem 52: 5009-12 (2010) Article DOI: 10.1021/jm900725r BindingDB Entry DOI: 10.7270/Q2TX3G8W
Merck Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Epoxide hydrolase 2 (Rattus norvegicus)	BDBM50295549 (4-(3-(pyridin-2-yl)-1,2,4-oxadiazol-5-yl)-N-(4-(tr...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	17	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of rat sEH				J Med Chem 52: 5009-12 (2010) Article DOI: 10.1021/jm900725r BindingDB Entry DOI: 10.7270/Q2TX3G8W
Merck Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
EBifunctional epoxide hydrolase 2 (Homo sapiens (Human))	BDBM50295549 (4-(3-(pyridin-2-yl)-1,2,4-oxadiazol-5-yl)-N-(4-(tr...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of human sEH in HEK293 cells assessed as conversion of 14,15-epoxyeicosatrienoic acid to 14,15-dihydroepoxyeicosatrienoic acid				J Med Chem 52: 5009-12 (2010) Article DOI: 10.1021/jm900725r BindingDB Entry DOI: 10.7270/Q2TX3G8W
Merck Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Cytochrome P450 2C9 (Homo sapiens (Human))	BDBM50295549 (4-(3-(pyridin-2-yl)-1,2,4-oxadiazol-5-yl)-N-(4-(tr...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of CYP2C9				J Med Chem 52: 5009-12 (2010) Article DOI: 10.1021/jm900725r BindingDB Entry DOI: 10.7270/Q2TX3G8W
Merck Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Sodium channel protein type 5 subunit alpha (Homo sapiens (Human))	BDBM50295549 (4-(3-(pyridin-2-yl)-1,2,4-oxadiazol-5-yl)-N-(4-(tr...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of Nav1.5 channel				J Med Chem 52: 5009-12 (2010) Article DOI: 10.1021/jm900725r BindingDB Entry DOI: 10.7270/Q2TX3G8W
Merck Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Cytochrome P450 3A4 (Homo sapiens (Human))	BDBM50295549 (4-(3-(pyridin-2-yl)-1,2,4-oxadiazol-5-yl)-N-(4-(tr...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of CYP3A4				J Med Chem 52: 5009-12 (2010) Article DOI: 10.1021/jm900725r BindingDB Entry DOI: 10.7270/Q2TX3G8W
Merck Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Calcium channel (Type L) (Homo sapiens (Human))	BDBM50295549 (4-(3-(pyridin-2-yl)-1,2,4-oxadiazol-5-yl)-N-(4-(tr...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of Cav 1.2 channel				J Med Chem 52: 5009-12 (2010) Article DOI: 10.1021/jm900725r BindingDB Entry DOI: 10.7270/Q2TX3G8W
Merck Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2 (Homo sapiens (Human))	BDBM50295549 (4-(3-(pyridin-2-yl)-1,2,4-oxadiazol-5-yl)-N-(4-(tr...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	8.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of IKr channel				J Med Chem 52: 5009-12 (2010) Article DOI: 10.1021/jm900725r BindingDB Entry DOI: 10.7270/Q2TX3G8W
Merck Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Cytochrome P450 2D6 (Homo sapiens (Human))	BDBM50295549 (4-(3-(pyridin-2-yl)-1,2,4-oxadiazol-5-yl)-N-(4-(tr...) Show SMILES Show InChI	PDB UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of CYP2D6				J Med Chem 52: 5009-12 (2010) Article DOI: 10.1021/jm900725r BindingDB Entry DOI: 10.7270/Q2TX3G8W
Merck Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair