Found 9 hits for monomerid = 50295550 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
EBifunctional epoxide hydrolase 2
(Homo sapiens (Human)) | BDBM50295550
(4-(3-(pyridin-2-yl)-1,2,4-oxadiazol-5-yl)-N-(6,7,8...)Show SMILES O=C(NC1CCc2ccccc2CC1)N1CCC(CC1)c1nc(no1)-c1ccccn1 Show InChI InChI=1S/C24H27N5O2/c30-24(26-20-10-8-17-5-1-2-6-18(17)9-11-20)29-15-12-19(13-16-29)23-27-22(28-31-23)21-7-3-4-14-25-21/h1-7,14,19-20H,8-13,15-16H2,(H,26,30) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 36 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description Inhibition of human sEH |
J Med Chem 52: 5009-12 (2010)
Article DOI: 10.1021/jm900725r BindingDB Entry DOI: 10.7270/Q2TX3G8W |
More data for this Ligand-Target Pair | |
Epoxide hydrolase 2
(Rattus norvegicus) | BDBM50295550
(4-(3-(pyridin-2-yl)-1,2,4-oxadiazol-5-yl)-N-(6,7,8...)Show SMILES O=C(NC1CCc2ccccc2CC1)N1CCC(CC1)c1nc(no1)-c1ccccn1 Show InChI InChI=1S/C24H27N5O2/c30-24(26-20-10-8-17-5-1-2-6-18(17)9-11-20)29-15-12-19(13-16-29)23-27-22(28-31-23)21-7-3-4-14-25-21/h1-7,14,19-20H,8-13,15-16H2,(H,26,30) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 15 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description Inhibition of rat sEH |
J Med Chem 52: 5009-12 (2010)
Article DOI: 10.1021/jm900725r BindingDB Entry DOI: 10.7270/Q2TX3G8W |
More data for this Ligand-Target Pair | |
EBifunctional epoxide hydrolase 2
(Homo sapiens (Human)) | BDBM50295550
(4-(3-(pyridin-2-yl)-1,2,4-oxadiazol-5-yl)-N-(6,7,8...)Show SMILES O=C(NC1CCc2ccccc2CC1)N1CCC(CC1)c1nc(no1)-c1ccccn1 Show InChI InChI=1S/C24H27N5O2/c30-24(26-20-10-8-17-5-1-2-6-18(17)9-11-20)29-15-12-19(13-16-29)23-27-22(28-31-23)21-7-3-4-14-25-21/h1-7,14,19-20H,8-13,15-16H2,(H,26,30) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 181 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description Inhibition of human sEH in HEK293 cells assessed as conversion of 14,15-epoxyeicosatrienoic acid to 14,15-dihydroepoxyeicosatrienoic acid |
J Med Chem 52: 5009-12 (2010)
Article DOI: 10.1021/jm900725r BindingDB Entry DOI: 10.7270/Q2TX3G8W |
More data for this Ligand-Target Pair | |
Epoxide hydrolase 1
(Homo sapiens (Human)) | BDBM50295550
(4-(3-(pyridin-2-yl)-1,2,4-oxadiazol-5-yl)-N-(6,7,8...)Show SMILES O=C(NC1CCc2ccccc2CC1)N1CCC(CC1)c1nc(no1)-c1ccccn1 Show InChI InChI=1S/C24H27N5O2/c30-24(26-20-10-8-17-5-1-2-6-18(17)9-11-20)29-15-12-19(13-16-29)23-27-22(28-31-23)21-7-3-4-14-25-21/h1-7,14,19-20H,8-13,15-16H2,(H,26,30) | KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description Inhibition of human mEH |
J Med Chem 52: 5009-12 (2010)
Article DOI: 10.1021/jm900725r BindingDB Entry DOI: 10.7270/Q2TX3G8W |
More data for this Ligand-Target Pair | |
Sodium channel protein type 5 subunit alpha
(Homo sapiens (Human)) | BDBM50295550
(4-(3-(pyridin-2-yl)-1,2,4-oxadiazol-5-yl)-N-(6,7,8...)Show SMILES O=C(NC1CCc2ccccc2CC1)N1CCC(CC1)c1nc(no1)-c1ccccn1 Show InChI InChI=1S/C24H27N5O2/c30-24(26-20-10-8-17-5-1-2-6-18(17)9-11-20)29-15-12-19(13-16-29)23-27-22(28-31-23)21-7-3-4-14-25-21/h1-7,14,19-20H,8-13,15-16H2,(H,26,30) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description Inhibition of Nav1.5 channel |
J Med Chem 52: 5009-12 (2010)
Article DOI: 10.1021/jm900725r BindingDB Entry DOI: 10.7270/Q2TX3G8W |
More data for this Ligand-Target Pair | |
Cytochrome P450 3A4
(Homo sapiens (Human)) | BDBM50295550
(4-(3-(pyridin-2-yl)-1,2,4-oxadiazol-5-yl)-N-(6,7,8...)Show SMILES O=C(NC1CCc2ccccc2CC1)N1CCC(CC1)c1nc(no1)-c1ccccn1 Show InChI InChI=1S/C24H27N5O2/c30-24(26-20-10-8-17-5-1-2-6-18(17)9-11-20)29-15-12-19(13-16-29)23-27-22(28-31-23)21-7-3-4-14-25-21/h1-7,14,19-20H,8-13,15-16H2,(H,26,30) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description Inhibition of CYP3A4 |
J Med Chem 52: 5009-12 (2010)
Article DOI: 10.1021/jm900725r BindingDB Entry DOI: 10.7270/Q2TX3G8W |
More data for this Ligand-Target Pair | |
Calcium channel (Type L)
(Homo sapiens (Human)) | BDBM50295550
(4-(3-(pyridin-2-yl)-1,2,4-oxadiazol-5-yl)-N-(6,7,8...)Show SMILES O=C(NC1CCc2ccccc2CC1)N1CCC(CC1)c1nc(no1)-c1ccccn1 Show InChI InChI=1S/C24H27N5O2/c30-24(26-20-10-8-17-5-1-2-6-18(17)9-11-20)29-15-12-19(13-16-29)23-27-22(28-31-23)21-7-3-4-14-25-21/h1-7,14,19-20H,8-13,15-16H2,(H,26,30) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description Inhibition of Cav 1.2 channel |
J Med Chem 52: 5009-12 (2010)
Article DOI: 10.1021/jm900725r BindingDB Entry DOI: 10.7270/Q2TX3G8W |
More data for this Ligand-Target Pair | |
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human)) | BDBM50295550
(4-(3-(pyridin-2-yl)-1,2,4-oxadiazol-5-yl)-N-(6,7,8...)Show SMILES O=C(NC1CCc2ccccc2CC1)N1CCC(CC1)c1nc(no1)-c1ccccn1 Show InChI InChI=1S/C24H27N5O2/c30-24(26-20-10-8-17-5-1-2-6-18(17)9-11-20)29-15-12-19(13-16-29)23-27-22(28-31-23)21-7-3-4-14-25-21/h1-7,14,19-20H,8-13,15-16H2,(H,26,30) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description Inhibition of IKr channel |
J Med Chem 52: 5009-12 (2010)
Article DOI: 10.1021/jm900725r BindingDB Entry DOI: 10.7270/Q2TX3G8W |
More data for this Ligand-Target Pair | |
Cytochrome P450 2D6
(Homo sapiens (Human)) | BDBM50295550
(4-(3-(pyridin-2-yl)-1,2,4-oxadiazol-5-yl)-N-(6,7,8...)Show SMILES O=C(NC1CCc2ccccc2CC1)N1CCC(CC1)c1nc(no1)-c1ccccn1 Show InChI InChI=1S/C24H27N5O2/c30-24(26-20-10-8-17-5-1-2-6-18(17)9-11-20)29-15-12-19(13-16-29)23-27-22(28-31-23)21-7-3-4-14-25-21/h1-7,14,19-20H,8-13,15-16H2,(H,26,30) | PDB
UniProtKB/SwissProt UniProtKB/TrEMBL
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description Inhibition of CYP2D6 |
J Med Chem 52: 5009-12 (2010)
Article DOI: 10.1021/jm900725r BindingDB Entry DOI: 10.7270/Q2TX3G8W |
More data for this Ligand-Target Pair | |