BDBM50295885 5-(biphenyl-4-yl)-4-(1-methyl-1H-indol-3-yl)pyrimidin-2-amine::CHEMBL559538

SMILES: Cn1cc(-c2nc(N)ncc2-c2ccc(cc2)-c2ccccc2)c2ccccc12

InChI Key: InChIKey=CVIMBUQNJRLCFV-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50295885   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Cyclin-dependent-like kinase 5 (Homo sapiens (Human))	BDBM50295885 (5-(biphenyl-4-yl)-4-(1-methyl-1H-indol-3-yl)pyrimi...) Show SMILES Cn1cc(-c2nc(N)ncc2-c2ccc(cc2)-c2ccccc2)c2ccccc12 Show InChI InChI=1S/C25H20N4/c1-29-16-22(20-9-5-6-10-23(20)29)24-21(15-27-25(26)28-24)19-13-11-18(12-14-19)17-7-3-2-4-8-17/h2-16H,1H3,(H2,26,27,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Clermont Universit£ Curated by ChEMBL					Assay Description Inhibition of human recombinant CDK5/p25				Bioorg Med Chem 17: 4420-4 (2009) Article DOI: 10.1016/j.bmc.2009.05.017 BindingDB Entry DOI: 10.7270/Q2639PSH
					More data for this Ligand-Target Pair
ERK-2 (Rattus norvegicus (rat))	BDBM50295885 (5-(biphenyl-4-yl)-4-(1-methyl-1H-indol-3-yl)pyrimi...) Show SMILES Cn1cc(-c2nc(N)ncc2-c2ccc(cc2)-c2ccccc2)c2ccccc12 Show InChI InChI=1S/C25H20N4/c1-29-16-22(20-9-5-6-10-23(20)29)24-21(15-27-25(26)28-24)19-13-11-18(12-14-19)17-7-3-2-4-8-17/h2-16H,1H3,(H2,26,27,28)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Clermont Universit£ Curated by ChEMBL					Assay Description Inhibition of rat recombinant Erk2				Bioorg Med Chem 17: 4420-4 (2009) Article DOI: 10.1016/j.bmc.2009.05.017 BindingDB Entry DOI: 10.7270/Q2639PSH
					More data for this Ligand-Target Pair
Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A (RAT)	BDBM50295885 (5-(biphenyl-4-yl)-4-(1-methyl-1H-indol-3-yl)pyrimi...) Show SMILES Cn1cc(-c2nc(N)ncc2-c2ccc(cc2)-c2ccccc2)c2ccccc12 Show InChI InChI=1S/C25H20N4/c1-29-16-22(20-9-5-6-10-23(20)29)24-21(15-27-25(26)28-24)19-13-11-18(12-14-19)17-7-3-2-4-8-17/h2-16H,1H3,(H2,26,27,28)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Clermont Universit£ Curated by ChEMBL					Assay Description Inhibition of rat recombinant DYRK1A expressed in Escherichia coli				Bioorg Med Chem 17: 4420-4 (2009) Article DOI: 10.1016/j.bmc.2009.05.017 BindingDB Entry DOI: 10.7270/Q2639PSH
					More data for this Ligand-Target Pair