BDBM50296807 5-ethyl-2-(2-(4-methylpiperazin-1-yl)pyridin-3-yl)-4H-benzo[d][1,3]oxazin-4-one::CHEMBL558846

SMILES: CCc1cccc2nc(oc(=O)c12)-c1cccnc1N1CCN(C)CC1

InChI Key: InChIKey=SRKNVQGMLSKJLN-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50296807   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Leukocyte elastase (Homo sapiens (Human))	BDBM50296807 (5-ethyl-2-(2-(4-methylpiperazin-1-yl)pyridin-3-yl)...) Show SMILES CCc1cccc2nc(oc(=O)c12)-c1cccnc1N1CCN(C)CC1 Show InChI InChI=1S/C20H22N4O2/c1-3-14-6-4-8-16-17(14)20(25)26-19(22-16)15-7-5-9-21-18(15)24-12-10-23(2)11-13-24/h4-9H,3,10-13H2,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	8.10	n/a	n/a	n/a	n/a	n/a	n/a
ActivX Biosciences, Inc Curated by ChEMBL					Assay Description Inhibition of human sputum neutrophil elastase by fluorescence based assay				Bioorg Med Chem Lett 19: 4743-6 (2009) Article DOI: 10.1016/j.bmcl.2009.06.053 BindingDB Entry DOI: 10.7270/Q2M32VT3
					More data for this Ligand-Target Pair