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SMILES: Fc1ccc2cc(CN3CC[C@H](C3)NC(=O)Cc3ccccc3)ccc2c1

InChI Key: InChIKey=QZWYQJYWTHDPMU-JOCHJYFZSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50297197   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
C-C chemokine receptor type 3


(Homo sapiens (Human))		BDBM50297197
PNG
(CHEMBL549514 | N-{(3R)-1-[(6-Fluoro-2-naphthyl)met...)
Show SMILES Fc1ccc2cc(CN3CC[C@H](C3)NC(=O)Cc3ccccc3)ccc2c1 |r|
Show InChI InChI=1S/C23H23FN2O/c24-21-9-8-19-12-18(6-7-20(19)14-21)15-26-11-10-22(16-26)25-23(27)13-17-4-2-1-3-5-17/h1-9,12,14,22H,10-11,13,15-16H2,(H,25,27)/t22-/m1/s1
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n/an/a 170n/an/an/an/an/an/a



Astellas Pharma Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium flux

Bioorg Med Chem 17: 5989-6002 (2009)


Article DOI: 10.1016/j.bmc.2009.06.066
BindingDB Entry DOI: 10.7270/Q2WD40NV
More data for this
Ligand-Target Pair