BindingDB PrimarySearch

BDBM50299971 4-Fluoro-N-{[(+)-(4S)-2-oxo-6-(1H-pyrazol-5-yl)-4-(trifluoromethyl)-1,4-dihydro-2H-3,1-benzoxazin-4-yl]methyl}benzamide::CHEMBL570571

SMILES: Fc1ccc(cc1)C(=O)NC[C@]1(OC(=O)Nc2ccc(cc12)-c1cc[nH]n1)C(F)(F)F

InChI Key: InChIKey=SMOJVTPALLWLKJ-LJQANCHMSA-N

Data: 8 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50299971
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Elongation of very long chain fatty acids protein 6 (Homo sapiens (Human))	BDBM50299971 (4-Fluoro-N-{[(+)-(4S)-2-oxo-6-(1H-pyrazol-5-yl)-4-...) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.60	n/a	n/a	n/a	n/a	n/a	n/a
Tsukuba Research Institute Curated by ChEMBL					Assay Description Inhibition of human ELOVL6 expressed in Pichia pastoris using palmitoyl-CoA by long chain fatty acyl-CoA elongation assay				J Med Chem 52: 7289-300 (2009) Article DOI: 10.1021/jm900915x BindingDB Entry DOI: 10.7270/Q2XK8FMB
Tsukuba Research Institute Curated by ChEMBL					More data for this Ligand-Target Pair
Elongation of very long chain fatty acids protein 6 (Mus musculus)	BDBM50299971 (4-Fluoro-N-{[(+)-(4S)-2-oxo-6-(1H-pyrazol-5-yl)-4-...) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.60	n/a	n/a	n/a	n/a	n/a	n/a
Tsukuba Research Institute Curated by ChEMBL					Assay Description Inhibition of ELOVL6 in mouse H2.35 cells assessed as elongation index				J Med Chem 52: 7289-300 (2009) Article DOI: 10.1021/jm900915x BindingDB Entry DOI: 10.7270/Q2XK8FMB
Tsukuba Research Institute Curated by ChEMBL					More data for this Ligand-Target Pair
Elongation of very long chain fatty acids protein 1 (Homo sapiens (Human))	BDBM50299971 (4-Fluoro-N-{[(+)-(4S)-2-oxo-6-(1H-pyrazol-5-yl)-4-...) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Tsukuba Research Institute Curated by ChEMBL					Assay Description Inhibition of human ELOVL1				J Med Chem 52: 7289-300 (2009) Article DOI: 10.1021/jm900915x BindingDB Entry DOI: 10.7270/Q2XK8FMB
Tsukuba Research Institute Curated by ChEMBL					More data for this Ligand-Target Pair
Elongation of very long chain fatty acids protein 6 (Mus musculus)	BDBM50299971 (4-Fluoro-N-{[(+)-(4S)-2-oxo-6-(1H-pyrazol-5-yl)-4-...) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	14	n/a	n/a	n/a	n/a	n/a	n/a
Tsukuba Research Institute Curated by ChEMBL					Assay Description Inhibition of mouse ELOVL6 expressed in Pichia pastoris using palmitoyl-CoA by long chain fatty acyl-CoA elongation assay				J Med Chem 52: 7289-300 (2009) Article DOI: 10.1021/jm900915x BindingDB Entry DOI: 10.7270/Q2XK8FMB
Tsukuba Research Institute Curated by ChEMBL					More data for this Ligand-Target Pair
Elongation of very long chain fatty acids protein 5 (Homo sapiens (Human))	BDBM50299971 (4-Fluoro-N-{[(+)-(4S)-2-oxo-6-(1H-pyrazol-5-yl)-4-...) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Tsukuba Research Institute Curated by ChEMBL					Assay Description Inhibition of human ELOVL5				J Med Chem 52: 7289-300 (2009) Article DOI: 10.1021/jm900915x BindingDB Entry DOI: 10.7270/Q2XK8FMB
Tsukuba Research Institute Curated by ChEMBL					More data for this Ligand-Target Pair
Elongation of very long chain fatty acids protein 3 (Homo sapiens (Human))	BDBM50299971 (4-Fluoro-N-{[(+)-(4S)-2-oxo-6-(1H-pyrazol-5-yl)-4-...) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	130	n/a	n/a	n/a	n/a	n/a	n/a
Tsukuba Research Institute Curated by ChEMBL					Assay Description Inhibition of human ELOVL3				J Med Chem 52: 7289-300 (2009) Article DOI: 10.1021/jm900915x BindingDB Entry DOI: 10.7270/Q2XK8FMB
Tsukuba Research Institute Curated by ChEMBL					More data for this Ligand-Target Pair
Elongation of very long chain fatty acids protein 3 (Mus musculus)	BDBM50299971 (4-Fluoro-N-{[(+)-(4S)-2-oxo-6-(1H-pyrazol-5-yl)-4-...) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	19	n/a	n/a	n/a	n/a	n/a	n/a
Tsukuba Research Institute Curated by ChEMBL					Assay Description Inhibition of mouse ELOVL3				J Med Chem 52: 7289-300 (2009) Article DOI: 10.1021/jm900915x BindingDB Entry DOI: 10.7270/Q2XK8FMB
Tsukuba Research Institute Curated by ChEMBL					More data for this Ligand-Target Pair
Elongation of very long chain fatty acids protein 2 (Homo sapiens (Human))	BDBM50299971 (4-Fluoro-N-{[(+)-(4S)-2-oxo-6-(1H-pyrazol-5-yl)-4-...) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Tsukuba Research Institute Curated by ChEMBL					Assay Description Inhibition of human ELOVL2				J Med Chem 52: 7289-300 (2009) Article DOI: 10.1021/jm900915x BindingDB Entry DOI: 10.7270/Q2XK8FMB
Tsukuba Research Institute Curated by ChEMBL					More data for this Ligand-Target Pair