BDBM50301973 2-(6-(3'-(aminomethyl)-5-hydroxybiphenyl-3-yloxy)-3,5-difluoropyridin-2-yloxy)-4-methylbenzoic acid::CHEMBL571566

SMILES: Cc1ccc(C(O)=O)c(Oc2nc(Oc3cc(O)cc(c3)-c3cccc(CN)c3)c(F)cc2F)c1

InChI Key: InChIKey=HITMUBIYWGPIML-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50301973   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Plasminogen (Homo sapiens (Human))	BDBM50301973 (2-(6-(3'-(aminomethyl)-5-hydroxybiphenyl-3-yloxy)-...) Show SMILES Cc1ccc(C(O)=O)c(Oc2nc(Oc3cc(O)cc(c3)-c3cccc(CN)c3)c(F)cc2F)c1 Show InChI InChI=1S/C26H20F2N2O5/c1-14-5-6-20(26(32)33)23(7-14)35-25-22(28)12-21(27)24(30-25)34-19-10-17(9-18(31)11-19)16-4-2-3-15(8-16)13-29/h2-12,31H,13,29H2,1H3,(H,32,33)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Berlex Biosciences Curated by ChEMBL					Assay Description Inhibition of plasmin				Bioorg Med Chem Lett 19: 5712-5 (2009) Article DOI: 10.1016/j.bmcl.2009.08.008 BindingDB Entry DOI: 10.7270/Q2JQ113Z
					More data for this Ligand-Target Pair
Urokinase-type plasminogen activator (Homo sapiens (Human))	BDBM50301973 (2-(6-(3'-(aminomethyl)-5-hydroxybiphenyl-3-yloxy)-...) Show SMILES Cc1ccc(C(O)=O)c(Oc2nc(Oc3cc(O)cc(c3)-c3cccc(CN)c3)c(F)cc2F)c1 Show InChI InChI=1S/C26H20F2N2O5/c1-14-5-6-20(26(32)33)23(7-14)35-25-22(28)12-21(27)24(30-25)34-19-10-17(9-18(31)11-19)16-4-2-3-15(8-16)13-29/h2-12,31H,13,29H2,1H3,(H,32,33)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	23	n/a	n/a	n/a	n/a	n/a	n/a
Berlex Biosciences Curated by ChEMBL					Assay Description Inhibition of uPA				Bioorg Med Chem Lett 19: 5712-5 (2009) Article DOI: 10.1016/j.bmcl.2009.08.008 BindingDB Entry DOI: 10.7270/Q2JQ113Z
					More data for this Ligand-Target Pair
Tissue-type plasminogen activator (Homo sapiens (Human))	BDBM50301973 (2-(6-(3'-(aminomethyl)-5-hydroxybiphenyl-3-yloxy)-...) Show SMILES Cc1ccc(C(O)=O)c(Oc2nc(Oc3cc(O)cc(c3)-c3cccc(CN)c3)c(F)cc2F)c1 Show InChI InChI=1S/C26H20F2N2O5/c1-14-5-6-20(26(32)33)23(7-14)35-25-22(28)12-21(27)24(30-25)34-19-10-17(9-18(31)11-19)16-4-2-3-15(8-16)13-29/h2-12,31H,13,29H2,1H3,(H,32,33)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.40E+4	n/a	n/a	n/a	n/a	n/a	n/a
Berlex Biosciences Curated by ChEMBL					Assay Description Inhibition of tPA				Bioorg Med Chem Lett 19: 5712-5 (2009) Article DOI: 10.1016/j.bmcl.2009.08.008 BindingDB Entry DOI: 10.7270/Q2JQ113Z
					More data for this Ligand-Target Pair