BDBM50302110 CHEMBL583032::N-(4-chloro-3-(1H-indol-2-yl)phenyl)-2-methyl-6-(trifluoromethyl)nicotinamide

SMILES: Cc1nc(ccc1C(=O)Nc1ccc(Cl)c(c1)-c1cc2ccccc2[nH]1)C(F)(F)F

InChI Key: InChIKey=IGXQTOXJKIJNKG-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50302110   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Sonic hedgehog protein (Mus musculus (Mouse))	BDBM50302110 (CHEMBL583032 | N-(4-chloro-3-(1H-indol-2-yl)phenyl...) Show SMILES Cc1nc(ccc1C(=O)Nc1ccc(Cl)c(c1)-c1cc2ccccc2[nH]1)C(F)(F)F Show InChI InChI=1S/C22H15ClF3N3O/c1-12-15(7-9-20(27-12)22(24,25)26)21(30)28-14-6-8-17(23)16(11-14)19-10-13-4-2-3-5-18(13)29-19/h2-11,29H,1H3,(H,28,30)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	500	n/a	n/a	n/a	n/a	n/a	n/a
Genentech Curated by ChEMBL					Assay Description Inhibition of SHH in mouse C3H10T1/2 cells by Gli-luciferase reporter gene assay				Bioorg Med Chem Lett 19: 5576-81 (2009) Article DOI: 10.1016/j.bmcl.2009.08.049 BindingDB Entry DOI: 10.7270/Q21R6QMJ
					More data for this Ligand-Target Pair