BDBM50302235 CHEMBL567866::tert-butyl 2-(3,4-dimethoxyphenyl)-2-(1,3-dioxo-4-(4-((S)-1-phenylethyl)piperazin-1-yl)isoindolin-2-yl)ethylcarbamate

SMILES: COc1ccc(cc1OC)C(CNC(=O)OC(C)(C)C)N1C(=O)c2cccc(N3CCN(CC3)[C@@H](C)c3ccccc3)c2C1=O

InChI Key: InChIKey=PDSUGZQHFWZCJV-UHFKCPIBSA-N

Data: 1 KI  1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50302235   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Urotensin II receptor (Homo sapiens (Human))	BDBM50302235 (CHEMBL567866 | tert-butyl 2-(3,4-dimethoxyphenyl)-...) Show SMILES COc1ccc(cc1OC)C(CNC(=O)OC(C)(C)C)N1C(=O)c2cccc(N3CCN(CC3)[C@@H](C)c3ccccc3)c2C1=O |r| Show InChI InChI=1S/C35H42N4O6/c1-23(24-11-8-7-9-12-24)37-17-19-38(20-18-37)27-14-10-13-26-31(27)33(41)39(32(26)40)28(22-36-34(42)45-35(2,3)4)25-15-16-29(43-5)30(21-25)44-6/h7-16,21,23,28H,17-20,22H2,1-6H3,(H,36,42)/t23-,28?/m0/s1	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	430	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Johnson& Johnson Pharmaceutical Research& Development Curated by ChEMBL					Assay Description Displacement of [125I]urotensin 2 from urotensin 2 receptor in human RMS13 cells by scintillation proximity assay				J Med Chem 52: 7432-45 (2009) Article DOI: 10.1021/jm900683d BindingDB Entry DOI: 10.7270/Q2S75GD7
					More data for this Ligand-Target Pair
UTS2R (RAT)	BDBM50302235 (CHEMBL567866 | tert-butyl 2-(3,4-dimethoxyphenyl)-...) Show SMILES COc1ccc(cc1OC)C(CNC(=O)OC(C)(C)C)N1C(=O)c2cccc(N3CCN(CC3)[C@@H](C)c3ccccc3)c2C1=O |r| Show InChI InChI=1S/C35H42N4O6/c1-23(24-11-8-7-9-12-24)37-17-19-38(20-18-37)27-14-10-13-26-31(27)33(41)39(32(26)40)28(22-36-34(42)45-35(2,3)4)25-15-16-29(43-5)30(21-25)44-6/h7-16,21,23,28H,17-20,22H2,1-6H3,(H,36,42)/t23-,28?/m0/s1	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	120	n/a	n/a	n/a	n/a	n/a	n/a
Johnson& Johnson Pharmaceutical Research& Development Curated by ChEMBL					Assay Description Antagonist activity at rat urotensin 2 receptor expressed in CHOK1 cells assessed as inhibition of urotensin 2-induced intracellular calcium mobiliza...				J Med Chem 52: 7432-45 (2009) Article DOI: 10.1021/jm900683d BindingDB Entry DOI: 10.7270/Q2S75GD7
					More data for this Ligand-Target Pair