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BDBM50302559 CHEMBL578049::N-(cis-4-{[4-(Dimethylamino)-5-methylpyrimidin-2-yl]amino}-cyclohexyl)-3,4-difluorobenzamide

SMILES: CN(C)c1nc(N[C@@H]2CC[C@@H](CC2)NC(=O)c2ccc(F)c(F)c2)ncc1C

InChI Key: InChIKey=RUWDCXXLJIBDAO-GASCZTMLSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50302559   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Melanin-concentrating hormone receptor


(Homo sapiens (Human))		BDBM50302559
PNG
(CHEMBL578049 | N-(cis-4-{[4-(Dimethylamino)-5-meth...)
Show SMILES CN(C)c1nc(N[C@@H]2CC[C@@H](CC2)NC(=O)c2ccc(F)c(F)c2)ncc1C |r,wU:10.13,7.6,(28.7,-29.71,;27.37,-30.48,;26.03,-29.71,;27.37,-32.02,;28.71,-32.78,;28.71,-34.33,;30.05,-35.1,;31.38,-34.33,;32.71,-35.11,;34.04,-34.34,;34.05,-32.8,;32.71,-32.03,;31.37,-32.8,;35.38,-32.04,;36.72,-32.81,;36.71,-34.35,;38.05,-32.04,;38.04,-30.51,;39.37,-29.74,;40.72,-30.51,;42.05,-29.74,;40.71,-32.05,;42.04,-32.83,;39.38,-32.82,;27.38,-35.11,;26.04,-34.34,;26.05,-32.79,;24.71,-32.02,)|
Show InChI InChI=1S/C20H25F2N5O/c1-12-11-23-20(26-18(12)27(2)3)25-15-7-5-14(6-8-15)24-19(28)13-4-9-16(21)17(22)10-13/h4,9-11,14-15H,5-8H2,1-3H3,(H,24,28)(H,23,25,26)/t14-,15+
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PubMed
n/an/a 2n/an/an/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Antagonist activity at CART form of human MCH1 receptor expressed in HEK293 cells coexpressing Galphaq assessed as inhibition of MCH-induced intracel...

Bioorg Med Chem Lett 19: 6166-71 (2009)


Article DOI: 10.1016/j.bmcl.2009.09.003
BindingDB Entry DOI: 10.7270/Q2KK9BVH
More data for this
Ligand-Target Pair