BDBM50304944 CHEMBL595474::N-(2-hydroxy-2-phenylethyl)-6-(4-(2-methylbenzoyl)piperidin-1-yl)pyridazine-3-carboxamide

SMILES: Cc1ccccc1C(=O)C1CCN(CC1)c1ccc(nn1)C(=O)NCC(O)c1ccccc1

InChI Key: InChIKey=QTBRDMNOZGAPAG-UHFFFAOYSA-N

Data: 5 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50304944   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Acyl-CoA desaturase 1 (Mus musculus)	BDBM50304944 (CHEMBL595474 | N-(2-hydroxy-2-phenylethyl)-6-(4-(2...) Show SMILES Cc1ccccc1C(=O)C1CCN(CC1)c1ccc(nn1)C(=O)NCC(O)c1ccccc1 Show InChI InChI=1S/C26H28N4O3/c1-18-7-5-6-10-21(18)25(32)20-13-15-30(16-14-20)24-12-11-22(28-29-24)26(33)27-17-23(31)19-8-3-2-4-9-19/h2-12,20,23,31H,13-17H2,1H3,(H,27,33)	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7	n/a	n/a	n/a	n/a	n/a	n/a
Daiichi Sankyo Co. Ltd Curated by ChEMBL					Assay Description Inhibition of Scd1 in mouse liver microsomes assessed as conversion of [14C]stearate to [14C]oleate pretreated for 10 mins measured after 60 mins				Bioorg Med Chem Lett 20: 341-5 (2010) Article DOI: 10.1016/j.bmcl.2009.10.101 BindingDB Entry DOI: 10.7270/Q23X86R7
					More data for this Ligand-Target Pair
Stearoyl-CoA desaturase 1 (Homo sapiens (Human))	BDBM50304944 (CHEMBL595474 | N-(2-hydroxy-2-phenylethyl)-6-(4-(2...) Show SMILES Cc1ccccc1C(=O)C1CCN(CC1)c1ccc(nn1)C(=O)NCC(O)c1ccccc1 Show InChI InChI=1S/C26H28N4O3/c1-18-7-5-6-10-21(18)25(32)20-13-15-30(16-14-20)24-12-11-22(28-29-24)26(33)27-17-23(31)19-8-3-2-4-9-19/h2-12,20,23,31H,13-17H2,1H3,(H,27,33)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	15	n/a	n/a	n/a	n/a	n/a	n/a
Daiichi Sankyo Co. Ltd Curated by ChEMBL					Assay Description Inhibition of Scd1 in human HEK-293A cell microsomes assessed as conversion of [14C]stearate to [14C]oleate pretreated for 10 mins measured after 60 ...				Bioorg Med Chem Lett 20: 341-5 (2010) Article DOI: 10.1016/j.bmcl.2009.10.101 BindingDB Entry DOI: 10.7270/Q23X86R7
					More data for this Ligand-Target Pair
Acyl-CoA desaturase 1 (Mus musculus)	BDBM50304944 (CHEMBL595474 | N-(2-hydroxy-2-phenylethyl)-6-(4-(2...) Show SMILES Cc1ccccc1C(=O)C1CCN(CC1)c1ccc(nn1)C(=O)NCC(O)c1ccccc1 Show InChI InChI=1S/C26H28N4O3/c1-18-7-5-6-10-21(18)25(32)20-13-15-30(16-14-20)24-12-11-22(28-29-24)26(33)27-17-23(31)19-8-3-2-4-9-19/h2-12,20,23,31H,13-17H2,1H3,(H,27,33)	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	15	n/a	n/a	n/a	n/a	n/a	n/a
Daiichi Sankyo Co. Ltd Curated by ChEMBL					Assay Description Inhibition of SCD1 in mouse microsomal liver S9 microsomal fraction assessed as conversion of [14C]stearate to [14C]oleate after 60 mins				Bioorg Med Chem Lett 20: 746-54 (2010) Article DOI: 10.1016/j.bmcl.2009.11.043 BindingDB Entry DOI: 10.7270/Q28C9WBJ
					More data for this Ligand-Target Pair
Stearoyl-CoA desaturase 1 (Homo sapiens (Human))	BDBM50304944 (CHEMBL595474 | N-(2-hydroxy-2-phenylethyl)-6-(4-(2...) Show SMILES Cc1ccccc1C(=O)C1CCN(CC1)c1ccc(nn1)C(=O)NCC(O)c1ccccc1 Show InChI InChI=1S/C26H28N4O3/c1-18-7-5-6-10-21(18)25(32)20-13-15-30(16-14-20)24-12-11-22(28-29-24)26(33)27-17-23(31)19-8-3-2-4-9-19/h2-12,20,23,31H,13-17H2,1H3,(H,27,33)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7	n/a	n/a	n/a	n/a	n/a	n/a
Daiichi Sankyo Co. Ltd Curated by ChEMBL					Assay Description Inhibition of SCD1 in human 293A cells assessed as conversion of [14C]stearate to [14C]oleate after 60 mins in presence of S9 microsomal fraction				Bioorg Med Chem Lett 20: 746-54 (2010) Article DOI: 10.1016/j.bmcl.2009.11.043 BindingDB Entry DOI: 10.7270/Q28C9WBJ
					More data for this Ligand-Target Pair
Stearoyl-CoA desaturase 1 (Homo sapiens (Human))	BDBM50304944 (CHEMBL595474 | N-(2-hydroxy-2-phenylethyl)-6-(4-(2...) Show SMILES Cc1ccccc1C(=O)C1CCN(CC1)c1ccc(nn1)C(=O)NCC(O)c1ccccc1 Show InChI InChI=1S/C26H28N4O3/c1-18-7-5-6-10-21(18)25(32)20-13-15-30(16-14-20)24-12-11-22(28-29-24)26(33)27-17-23(31)19-8-3-2-4-9-19/h2-12,20,23,31H,13-17H2,1H3,(H,27,33)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	51	n/a	n/a	n/a	n/a	n/a	n/a
Daiichi Sankyo Co. Ltd Curated by ChEMBL					Assay Description Inhibition of human Scd1 expressed in HEK-293A cells assessed as conversion of [14C]stearate to [14C]oleate pretreated for 30 mins measured after 4 h...				Bioorg Med Chem Lett 20: 341-5 (2010) Article DOI: 10.1016/j.bmcl.2009.10.101 BindingDB Entry DOI: 10.7270/Q23X86R7
					More data for this Ligand-Target Pair