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SMILES: COC(=O)CC1Nc2ccccc2-c2ccnc3[nH]cc1c23

InChI Key: InChIKey=RKLQUVRDCJEAGP-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50305162   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM50305162
PNG
(CHEMBL595397 | Methyl 2-{8,12,14-triazatetracyclo[...)
Show SMILES COC(=O)CC1Nc2ccccc2-c2ccnc3[nH]cc1c23
Show InChI InChI=1S/C17H15N3O2/c1-22-15(21)8-14-12-9-19-17-16(12)11(6-7-18-17)10-4-2-3-5-13(10)20-14/h2-7,9,14,20H,8H2,1H3,(H,18,19)
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Article
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 460n/an/an/an/an/an/an/an/a



Vertex Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of JAK2 by radiometric assay

Bioorg Med Chem Lett 20: 153-6 (2010)


Article DOI: 10.1016/j.bmcl.2009.11.021
BindingDB Entry DOI: 10.7270/Q2PN95RQ
More data for this
Ligand-Target Pair