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SMILES: N1C(c2c[nH]c3nccc(-c4ccccc14)c23)c1ccncc1

InChI Key: InChIKey=GIBIHBNBNTZABW-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50305183   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM50305183
PNG
(9-(pyridin-4-yl)-8,12,14-triazatetracyclo[8.6.1.0^...)
Show SMILES N1C(c2c[nH]c3nccc(-c4ccccc14)c23)c1ccncc1
Show InChI InChI=1S/C19H14N4/c1-2-4-16-13(3-1)14-7-10-21-19-17(14)15(11-22-19)18(23-16)12-5-8-20-9-6-12/h1-11,18,23H,(H,21,22)
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Article
PubMed
 1.30E+3n/an/an/an/an/an/an/an/a



Vertex Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of JAK2 by radiometric assay

Bioorg Med Chem Lett 20: 153-6 (2010)


Article DOI: 10.1016/j.bmcl.2009.11.021
BindingDB Entry DOI: 10.7270/Q2PN95RQ
More data for this
Ligand-Target Pair