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SMILES: Fc1cccc(c1)C1Nc2ccccc2-c2ncnc3[nH]cc1c23

InChI Key: InChIKey=HEMDFSGBBQGHGS-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50305187   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM50305187
PNG
(9-(3-fluorophenyl)-8,12,14,16-tetraazatetracyclo[8...)
Show SMILES Fc1cccc(c1)C1Nc2ccccc2-c2ncnc3[nH]cc1c23
Show InChI InChI=1S/C19H13FN4/c20-12-5-3-4-11(8-12)17-14-9-21-19-16(14)18(22-10-23-19)13-6-1-2-7-15(13)24-17/h1-10,17,24H,(H,21,22,23)
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Article
PubMed
 1.50E+3n/an/an/an/an/an/an/an/a



Vertex Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of JAK2 by radiometric assay

Bioorg Med Chem Lett 20: 153-6 (2010)


Article DOI: 10.1016/j.bmcl.2009.11.021
BindingDB Entry DOI: 10.7270/Q2PN95RQ
More data for this
Ligand-Target Pair