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SMILES: CCOC(=O)C1(Nc2ccccc2-c2ncnc3[nH]cc1c23)c1ccc(O)cc1

InChI Key: InChIKey=OFXSAXAQVKKCEQ-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50305195   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM50305195
PNG
(CHEMBL602100 | Ethyl 9-(4-hydroxyphenyl)-8,12,14,1...)
Show SMILES CCOC(=O)C1(Nc2ccccc2-c2ncnc3[nH]cc1c23)c1ccc(O)cc1
Show InChI InChI=1S/C22H18N4O3/c1-2-29-21(28)22(13-7-9-14(27)10-8-13)16-11-23-20-18(16)19(24-12-25-20)15-5-3-4-6-17(15)26-22/h3-12,26-27H,2H2,1H3,(H,23,24,25)
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Article
PubMed
 630n/an/an/an/an/an/an/an/a



Vertex Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of JAK2 by radiometric assay

Bioorg Med Chem Lett 20: 153-6 (2010)


Article DOI: 10.1016/j.bmcl.2009.11.021
BindingDB Entry DOI: 10.7270/Q2PN95RQ
More data for this
Ligand-Target Pair