BDBM50306107 CHEMBL604995::N-(2-hydroxy-2-phenylethyl)-6-(1-oxo-3,4-dihydro-1H-spiro[naphthalene-2,4'-piperidine]-1'-yl)pyridazine-3-carboxamide

SMILES: OC(CNC(=O)c1ccc(nn1)N1CCC2(CC1)CCc1ccccc1C2=O)c1ccccc1

InChI Key: InChIKey=FQIFULLUVUVEGR-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50306107   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Acyl-CoA desaturase 1 (Mus musculus)	BDBM50306107 (CHEMBL604995 | N-(2-hydroxy-2-phenylethyl)-6-(1-ox...) Show SMILES OC(CNC(=O)c1ccc(nn1)N1CCC2(CC1)CCc1ccccc1C2=O)c1ccccc1 Show InChI InChI=1S/C27H28N4O3/c32-23(20-7-2-1-3-8-20)18-28-26(34)22-10-11-24(30-29-22)31-16-14-27(15-17-31)13-12-19-6-4-5-9-21(19)25(27)33/h1-11,23,32H,12-18H2,(H,28,34)	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	570	n/a	n/a	n/a	n/a	n/a	n/a
Daiichi Sankyo Co. Ltd Curated by ChEMBL					Assay Description Inhibition of SCD1 in mouse microsomal liver S9 microsomal fraction assessed as conversion of [14C]stearate to [14C]oleate after 60 mins				Bioorg Med Chem Lett 20: 746-54 (2010) Article DOI: 10.1016/j.bmcl.2009.11.043 BindingDB Entry DOI: 10.7270/Q28C9WBJ
					More data for this Ligand-Target Pair
Stearoyl-CoA desaturase 1 (Homo sapiens (Human))	BDBM50306107 (CHEMBL604995 | N-(2-hydroxy-2-phenylethyl)-6-(1-ox...) Show SMILES OC(CNC(=O)c1ccc(nn1)N1CCC2(CC1)CCc1ccccc1C2=O)c1ccccc1 Show InChI InChI=1S/C27H28N4O3/c32-23(20-7-2-1-3-8-20)18-28-26(34)22-10-11-24(30-29-22)31-16-14-27(15-17-31)13-12-19-6-4-5-9-21(19)25(27)33/h1-11,23,32H,12-18H2,(H,28,34)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
Daiichi Sankyo Co. Ltd Curated by ChEMBL					Assay Description Inhibition of SCD1 in human 293A cells assessed as conversion of [14C]stearate to [14C]oleate after 60 mins in presence of S9 microsomal fraction				Bioorg Med Chem Lett 20: 746-54 (2010) Article DOI: 10.1016/j.bmcl.2009.11.043 BindingDB Entry DOI: 10.7270/Q28C9WBJ
					More data for this Ligand-Target Pair