BDBM50308176 1-[3-(2-Naphthylsulfonyl)-1H-indazol-5-yl]piperidin-4-amine::CHEMBL603483

SMILES: NC1CCN(CC1)c1ccc2[nH]nc(c2c1)S(=O)(=O)c1ccc2ccccc2c1

InChI Key: InChIKey=OYOYEIIOGFLVQY-UHFFFAOYSA-N

Data: 2 KI  1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50308176   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
5-hydroxytryptamine receptor 6 (Homo sapiens (Human))	BDBM50308176 (1-[3-(2-Naphthylsulfonyl)-1H-indazol-5-yl]piperidi...) Show SMILES NC1CCN(CC1)c1ccc2[nH]nc(c2c1)S(=O)(=O)c1ccc2ccccc2c1 Show InChI InChI=1S/C22H22N4O2S/c23-17-9-11-26(12-10-17)18-6-8-21-20(14-18)22(25-24-21)29(27,28)19-7-5-15-3-1-2-4-16(15)13-19/h1-8,13-14,17H,9-12,23H2,(H,24,25)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	18.2	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Displacement of [3H]LSD from human 5HT6 receptor by scintillation counting				J Med Chem 53: 2521-7 (2010) Article DOI: 10.1021/jm901674f BindingDB Entry DOI: 10.7270/Q22B8Z43
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2B (Homo sapiens (Human))	BDBM50308176 (1-[3-(2-Naphthylsulfonyl)-1H-indazol-5-yl]piperidi...) Show SMILES NC1CCN(CC1)c1ccc2[nH]nc(c2c1)S(=O)(=O)c1ccc2ccccc2c1 Show InChI InChI=1S/C22H22N4O2S/c23-17-9-11-26(12-10-17)18-6-8-21-20(14-18)22(25-24-21)29(27,28)19-7-5-15-3-1-2-4-16(15)13-19/h1-8,13-14,17H,9-12,23H2,(H,24,25)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	1.36E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Displacement of [3H]5HT from human 5HT2B receptor expressed in CHO cells by scintillation counting				J Med Chem 53: 2521-7 (2010) Article DOI: 10.1021/jm901674f BindingDB Entry DOI: 10.7270/Q22B8Z43
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 6 (Homo sapiens (Human))	BDBM50308176 (1-[3-(2-Naphthylsulfonyl)-1H-indazol-5-yl]piperidi...) Show SMILES NC1CCN(CC1)c1ccc2[nH]nc(c2c1)S(=O)(=O)c1ccc2ccccc2c1 Show InChI InChI=1S/C22H22N4O2S/c23-17-9-11-26(12-10-17)18-6-8-21-20(14-18)22(25-24-21)29(27,28)19-7-5-15-3-1-2-4-16(15)13-19/h1-8,13-14,17H,9-12,23H2,(H,24,25)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	88.9	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Antagonist activity at human cloned 5HT6 receptor expressed in human HeLa cells assessed as intracellular cAMP formation by RIA				J Med Chem 53: 2521-7 (2010) Article DOI: 10.1021/jm901674f BindingDB Entry DOI: 10.7270/Q22B8Z43
					More data for this Ligand-Target Pair