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SMILES: O=C1Cc2cnc3cc(nn3c2-c2ccccc2N1)-c1ccccc1

InChI Key: InChIKey=ZTJVEYJKWKUOKL-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50308208   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Insulin receptor (Homo sapiens (Human))	BDBM50308208 (2-Phenyl-6,8-dihydro-7H-pyrazolo[5',1':2,3]pyrimid...) Show SMILES O=C1Cc2cnc3cc(nn3c2-c2ccccc2N1)-c1ccccc1 Show InChI InChI=1S/C20H14N4O/c25-19-10-14-12-21-18-11-17(13-6-2-1-3-7-13)23-24(18)20(14)15-8-4-5-9-16(15)22-19/h1-9,11-12H,10H2,(H,22,25)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Technische Universitat Braunschweig Curated by ChEMBL					Assay Description Inhibition of INSR assessed as [33Pi] incorporation by microplate scintillation counting in presence of 1 uM ATP				J Med Chem 53: 2433-42 (2010) Article DOI: 10.1021/jm901388c BindingDB Entry DOI: 10.7270/Q24J0G22
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50308208 (2-Phenyl-6,8-dihydro-7H-pyrazolo[5',1':2,3]pyrimid...) Show SMILES O=C1Cc2cnc3cc(nn3c2-c2ccccc2N1)-c1ccccc1 Show InChI InChI=1S/C20H14N4O/c25-19-10-14-12-21-18-11-17(13-6-2-1-3-7-13)23-24(18)20(14)15-8-4-5-9-16(15)22-19/h1-9,11-12H,10H2,(H,22,25)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	630	n/a	n/a	n/a	n/a	n/a	n/a
Technische Universitat Braunschweig Curated by ChEMBL					Assay Description Inhibition of VEGFR2 assessed as [33Pi] incorporation by microplate scintillation counting in presence of 1 uM ATP				J Med Chem 53: 2433-42 (2010) Article DOI: 10.1021/jm901388c BindingDB Entry DOI: 10.7270/Q24J0G22
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase PLK1 (Homo sapiens (Human))	BDBM50308208 (2-Phenyl-6,8-dihydro-7H-pyrazolo[5',1':2,3]pyrimid...) Show SMILES O=C1Cc2cnc3cc(nn3c2-c2ccccc2N1)-c1ccccc1 Show InChI InChI=1S/C20H14N4O/c25-19-10-14-12-21-18-11-17(13-6-2-1-3-7-13)23-24(18)20(14)15-8-4-5-9-16(15)22-19/h1-9,11-12H,10H2,(H,22,25)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Technische Universitat Braunschweig Curated by ChEMBL					Assay Description Inhibition of PLK1 assessed as [33Pi] incorporation by microplate scintillation counting in presence of 1 uM ATP				J Med Chem 53: 2433-42 (2010) Article DOI: 10.1021/jm901388c BindingDB Entry DOI: 10.7270/Q24J0G22
					More data for this Ligand-Target Pair