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SMILES: COc1ccc-2c(NC(=O)Cc3cnc4cc(nn4c-23)-c2ccccc2)c1

InChI Key: InChIKey=JCVZSDHNGQFOMA-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50308210   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Insulin receptor (Homo sapiens (Human))	BDBM50308210 (10-Methoxy-2-phenyl-6,8-dihydro-7H-pyrazolo[5',1':...) Show SMILES COc1ccc-2c(NC(=O)Cc3cnc4cc(nn4c-23)-c2ccccc2)c1 Show InChI InChI=1S/C21H16N4O2/c1-27-15-7-8-16-18(10-15)23-20(26)9-14-12-22-19-11-17(24-25(19)21(14)16)13-5-3-2-4-6-13/h2-8,10-12H,9H2,1H3,(H,23,26)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.10E+4	n/a	n/a	n/a	n/a	n/a	n/a
Technische Universitat Braunschweig Curated by ChEMBL					Assay Description Inhibition of INSR assessed as [33Pi] incorporation by microplate scintillation counting in presence of 1 uM ATP				J Med Chem 53: 2433-42 (2010) Article DOI: 10.1021/jm901388c BindingDB Entry DOI: 10.7270/Q24J0G22
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50308210 (10-Methoxy-2-phenyl-6,8-dihydro-7H-pyrazolo[5',1':...) Show SMILES COc1ccc-2c(NC(=O)Cc3cnc4cc(nn4c-23)-c2ccccc2)c1 Show InChI InChI=1S/C21H16N4O2/c1-27-15-7-8-16-18(10-15)23-20(26)9-14-12-22-19-11-17(24-25(19)21(14)16)13-5-3-2-4-6-13/h2-8,10-12H,9H2,1H3,(H,23,26)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
Technische Universitat Braunschweig Curated by ChEMBL					Assay Description Inhibition of VEGFR2 assessed as [33Pi] incorporation by microplate scintillation counting in presence of 1 uM ATP				J Med Chem 53: 2433-42 (2010) Article DOI: 10.1021/jm901388c BindingDB Entry DOI: 10.7270/Q24J0G22
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase PLK1 (Homo sapiens (Human))	BDBM50308210 (10-Methoxy-2-phenyl-6,8-dihydro-7H-pyrazolo[5',1':...) Show SMILES COc1ccc-2c(NC(=O)Cc3cnc4cc(nn4c-23)-c2ccccc2)c1 Show InChI InChI=1S/C21H16N4O2/c1-27-15-7-8-16-18(10-15)23-20(26)9-14-12-22-19-11-17(24-25(19)21(14)16)13-5-3-2-4-6-13/h2-8,10-12H,9H2,1H3,(H,23,26)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.70E+4	n/a	n/a	n/a	n/a	n/a	n/a
Technische Universitat Braunschweig Curated by ChEMBL					Assay Description Inhibition of PLK1 assessed as [33Pi] incorporation by microplate scintillation counting in presence of 1 uM ATP				J Med Chem 53: 2433-42 (2010) Article DOI: 10.1021/jm901388c BindingDB Entry DOI: 10.7270/Q24J0G22
					More data for this Ligand-Target Pair