BDBM50308295 (S)-7-(2-(Hydroxyamino)-2-oxoethoxy)-N-o-tolyl-1,2,3,4-tetrahydroisoquinoline-3-carboxamide hydrochloride::CHEMBL599462

SMILES: Cc1ccccc1NC(=O)[C@@H]1Cc2ccc(OCC(=O)NO)cc2CN1

InChI Key: InChIKey=ZXVSXNSLJRCINL-KRWDZBQOSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50308295   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Histone deacetylase 8 (Homo sapiens (Human))	BDBM50308295 ((S)-7-(2-(Hydroxyamino)-2-oxoethoxy)-N-o-tolyl-1,2...) Show SMILES Cc1ccccc1NC(=O)[C@@H]1Cc2ccc(OCC(=O)NO)cc2CN1 |r| Show InChI InChI=1S/C19H21N3O4/c1-12-4-2-3-5-16(12)21-19(24)17-9-13-6-7-15(8-14(13)10-20-17)26-11-18(23)22-25/h2-8,17,20,25H,9-11H2,1H3,(H,21,24)(H,22,23)/t17-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.13E+3	n/a	n/a	n/a	n/a	n/a	n/a
Shandong University Curated by ChEMBL					Assay Description Inhibition of HDAC8 expressed in Escherichia coli assessed as Boc-Lys (acetyl)-AMC substrate hydrolysis by fluorimetric assay				Bioorg Med Chem 18: 1761-72 (2010) Article DOI: 10.1016/j.bmc.2010.01.060 BindingDB Entry DOI: 10.7270/Q2JD4WX3
					More data for this Ligand-Target Pair