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SMILES: CC(C)(C)NC(=O)[C@@H]1Cc2ccc(OCC(=O)NO)cc2CN1

InChI Key: InChIKey=JZXLXKGJMOSPRO-ZDUSSCGKSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50308315   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Histone deacetylase 8


(Homo sapiens (Human))		BDBM50308315
PNG
((S)-N-tert-Butyl-7-(2-(hydroxyamino)-2-oxoethoxy)-...)
Show SMILES CC(C)(C)NC(=O)[C@@H]1Cc2ccc(OCC(=O)NO)cc2CN1 |r|
Show InChI InChI=1S/C16H23N3O4/c1-16(2,3)18-15(21)13-7-10-4-5-12(6-11(10)8-17-13)23-9-14(20)19-22/h4-6,13,17,22H,7-9H2,1-3H3,(H,18,21)(H,19,20)/t13-/m0/s1
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Similars
Article
PubMed
n/an/a 1.22E+4n/an/an/an/an/an/a



Shandong University

Curated by ChEMBL


Assay Description
Inhibition of HDAC8 expressed in Escherichia coli assessed as Boc-Lys (acetyl)-AMC substrate hydrolysis by fluorimetric assay

Bioorg Med Chem 18: 1761-72 (2010)


Article DOI: 10.1016/j.bmc.2010.01.060
BindingDB Entry DOI: 10.7270/Q2JD4WX3
More data for this
Ligand-Target Pair