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SMILES: ONC(=O)COc1ccc2Cc3c(O)n(-c4ccccc4)c(=O)n3Cc2c1

InChI Key: InChIKey=SSMHNWBDKGKFOD-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50308317   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Histone deacetylase 8


(Homo sapiens (Human))		BDBM50308317
PNG
((S)-Benzyl 7-(2-(hydroxyamino)-2-oxoethoxy)-3-(phe...)
Show SMILES ONC(=O)COc1ccc2Cc3c(O)n(-c4ccccc4)c(=O)n3Cc2c1
Show InChI InChI=1S/C19H17N3O5/c23-17(20-26)11-27-15-7-6-12-9-16-18(24)22(14-4-2-1-3-5-14)19(25)21(16)10-13(12)8-15/h1-8,24,26H,9-11H2,(H,20,23)
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Similars
Article
PubMed
n/an/a>5.00E+4n/an/an/an/an/an/a



Shandong University

Curated by ChEMBL


Assay Description
Inhibition of HDAC8 expressed in Escherichia coli assessed as Boc-Lys (acetyl)-AMC substrate hydrolysis by fluorimetric assay

Bioorg Med Chem 18: 1761-72 (2010)


Article DOI: 10.1016/j.bmc.2010.01.060
BindingDB Entry DOI: 10.7270/Q2JD4WX3
More data for this
Ligand-Target Pair