BDBM50308532 (14E)-14-ethylidene-6-methoxy-19-(methoxycarbonyl)-2-methyl-19-{[(3,4,5-trimethoxyphenyl)carbonyloxy]methyl}-18-oxa-2,12-diazahexacyclo[9.6.1.1^{9,15}.0^{1,9}.0^{3,8}.0^{12,17}]nonadeca-3(8),4,6-trien-12-ium-12-olate::CHEMBL602444
SMILES: COC(=O)[C@]1(COC(=O)c2cc(OC)c(OC)c(OC)c2)[C@H]2C[C@H]3[C@]45O[C@@H](C[C@]14c1cc(OC)ccc1N5C)[N+]3([O-])C\C2=C\C
InChI Key: InChIKey=LELCCVFXAKTLGY-AVGKHWAZSA-N
Data: 2 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sodium/glucose cotransporter 2 (Homo sapiens (Human)) | BDBM50308532![]() ((14E)-14-ethylidene-6-methoxy-19-(methoxycarbonyl)...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.10E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Hoshi University Curated by ChEMBL | Assay Description Inhibition of alpha-D-[U-14C]glucopyranoside uptake at human SGLT2 expressed in african green monkey COS1 cells after 30 mins by liquid scintillation... | Bioorg Med Chem 18: 2152-8 (2010) Article DOI: 10.1016/j.bmc.2010.01.077 BindingDB Entry DOI: 10.7270/Q2HD7VSQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium/glucose cotransporter 1 (SGLT1) (Homo sapiens (Human)) | BDBM50308532![]() ((14E)-14-ethylidene-6-methoxy-19-(methoxycarbonyl)...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 4.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Hoshi University Curated by ChEMBL | Assay Description Inhibition of alpha-D-[U-14C]glucopyranoside uptake at human SGLT1 expressed in african green monkey COS1 cells after 30 mins by liquid scintillation... | Bioorg Med Chem 18: 2152-8 (2010) Article DOI: 10.1016/j.bmc.2010.01.077 BindingDB Entry DOI: 10.7270/Q2HD7VSQ | |||||||||||
More data for this Ligand-Target Pair |