BDBM50308533 CHEMBL589254::Methyl (14E)-14-ethylidene-6-methoxy-2-methyl-19-({[(2E)-3-phenylprop-2-enoyl]oxy}methyl)-18-oxa-2,12-diazahexacyclo[9.6.1.1^{9,15}.0^{1,9}.0^{3,8}.0^{12,17}]nonadeca-3(8),4,6-triene-19-carboxylate

SMILES: COC(=O)[C@]1(COC(=O)\C=C\c2ccccc2)[C@H]2C[C@@H]3N(C\C2=C\C)[C@@H]2C[C@]11c4cc(OC)ccc4N(C)[C@]31O2

InChI Key: InChIKey=AGIAKZIUEDYVAM-JNSBEWQRSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50308533   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Sodium/glucose cotransporter 2 (Homo sapiens (Human))	BDBM50308533 (CHEMBL589254 | Methyl (14E)-14-ethylidene-6-methox...) Show SMILES COC(=O)[C@]1(COC(=O)\C=C\c2ccccc2)[C@H]2C[C@@H]3N(C\C2=C\C)[C@@H]2C[C@]11c4cc(OC)ccc4N(C)[C@]31O2 |r| Show InChI InChI=1S/C32H34N2O6/c1-5-21-18-34-26-16-23(21)30(29(36)38-4,19-39-28(35)14-11-20-9-7-6-8-10-20)31-17-27(34)40-32(26,31)33(2)25-13-12-22(37-3)15-24(25)31/h5-15,23,26-27H,16-19H2,1-4H3/b14-11+,21-5-/t23-,26-,27-,30-,31-,32-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Hoshi University Curated by ChEMBL					Assay Description Inhibition of alpha-D-[U-14C]glucopyranoside uptake at human SGLT2 expressed in african green monkey COS1 cells after 30 mins by liquid scintillation...				Bioorg Med Chem 18: 2152-8 (2010) Article DOI: 10.1016/j.bmc.2010.01.077 BindingDB Entry DOI: 10.7270/Q2HD7VSQ
					More data for this Ligand-Target Pair
Sodium/glucose cotransporter 1 (SGLT1) (Homo sapiens (Human))	BDBM50308533 (CHEMBL589254 | Methyl (14E)-14-ethylidene-6-methox...) Show SMILES COC(=O)[C@]1(COC(=O)\C=C\c2ccccc2)[C@H]2C[C@@H]3N(C\C2=C\C)[C@@H]2C[C@]11c4cc(OC)ccc4N(C)[C@]31O2 |r| Show InChI InChI=1S/C32H34N2O6/c1-5-21-18-34-26-16-23(21)30(29(36)38-4,19-39-28(35)14-11-20-9-7-6-8-10-20)31-17-27(34)40-32(26,31)33(2)25-13-12-22(37-3)15-24(25)31/h5-15,23,26-27H,16-19H2,1-4H3/b14-11+,21-5-/t23-,26-,27-,30-,31-,32-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Hoshi University Curated by ChEMBL					Assay Description Inhibition of alpha-D-[U-14C]glucopyranoside uptake at human SGLT1 expressed in african green monkey COS1 cells after 30 mins by liquid scintillation...				Bioorg Med Chem 18: 2152-8 (2010) Article DOI: 10.1016/j.bmc.2010.01.077 BindingDB Entry DOI: 10.7270/Q2HD7VSQ
					More data for this Ligand-Target Pair