BDBM50309270 2-(4-(4-chlorophenyl)-2-(4-phenoxyphenyl)thiazol-5-yl)acetic acid::CHEMBL590090

SMILES: OC(=O)Cc1sc(nc1-c1ccc(Cl)cc1)-c1ccc(Oc2ccccc2)cc1

InChI Key: InChIKey=ISRQTYUCKOQIQL-UHFFFAOYSA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50309270   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
G protein-coupled receptor 44 (Homo sapiens (Human))	BDBM50309270 (2-(4-(4-chlorophenyl)-2-(4-phenoxyphenyl)thiazol-5...) Show SMILES OC(=O)Cc1sc(nc1-c1ccc(Cl)cc1)-c1ccc(Oc2ccccc2)cc1 Show InChI InChI=1S/C23H16ClNO3S/c24-17-10-6-15(7-11-17)22-20(14-21(26)27)29-23(25-22)16-8-12-19(13-9-16)28-18-4-2-1-3-5-18/h1-13H,14H2,(H,26,27)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
7TM Pharma A/S Curated by ChEMBL					Assay Description Antagonist activity at human CRTH2 receptor expressed in HEK285-7 cells assessed as inhibition of beta arrestin translocation by bioluminescence reso...				Bioorg Med Chem Lett 20: 1181-5 (2010) Article DOI: 10.1016/j.bmcl.2009.12.015 BindingDB Entry DOI: 10.7270/Q2PR7W35
					More data for this Ligand-Target Pair
G protein-coupled receptor 44 (Homo sapiens (Human))	BDBM50309270 (2-(4-(4-chlorophenyl)-2-(4-phenoxyphenyl)thiazol-5...) Show SMILES OC(=O)Cc1sc(nc1-c1ccc(Cl)cc1)-c1ccc(Oc2ccccc2)cc1 Show InChI InChI=1S/C23H16ClNO3S/c24-17-10-6-15(7-11-17)22-20(14-21(26)27)29-23(25-22)16-8-12-19(13-9-16)28-18-4-2-1-3-5-18/h1-13H,14H2,(H,26,27)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	93	n/a	n/a	n/a	n/a	n/a	n/a
7TM Pharma A/S Curated by ChEMBL					Assay Description Displacement of[3H]PGD2 from human CRTH2 receptor expressed in african green monkey COS7 cells				Bioorg Med Chem Lett 20: 1177-80 (2010) Article DOI: 10.1016/j.bmcl.2009.12.008 BindingDB Entry DOI: 10.7270/Q25T3KMP
					More data for this Ligand-Target Pair
G protein-coupled receptor 44 (Homo sapiens (Human))	BDBM50309270 (2-(4-(4-chlorophenyl)-2-(4-phenoxyphenyl)thiazol-5...) Show SMILES OC(=O)Cc1sc(nc1-c1ccc(Cl)cc1)-c1ccc(Oc2ccccc2)cc1 Show InChI InChI=1S/C23H16ClNO3S/c24-17-10-6-15(7-11-17)22-20(14-21(26)27)29-23(25-22)16-8-12-19(13-9-16)28-18-4-2-1-3-5-18/h1-13H,14H2,(H,26,27)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	93	n/a	n/a	n/a	n/a	n/a	n/a
7TM Pharma A/S Curated by ChEMBL					Assay Description Antagonist activity at human CRTH2 receptor expressed in HEK285-7 cells assessed as inhibition of beta arrestin translocation by bioluminescence reso...				Bioorg Med Chem Lett 20: 1177-80 (2010) Article DOI: 10.1016/j.bmcl.2009.12.008 BindingDB Entry DOI: 10.7270/Q25T3KMP
					More data for this Ligand-Target Pair
G protein-coupled receptor 44 (Homo sapiens (Human))	BDBM50309270 (2-(4-(4-chlorophenyl)-2-(4-phenoxyphenyl)thiazol-5...) Show SMILES OC(=O)Cc1sc(nc1-c1ccc(Cl)cc1)-c1ccc(Oc2ccccc2)cc1 Show InChI InChI=1S/C23H16ClNO3S/c24-17-10-6-15(7-11-17)22-20(14-21(26)27)29-23(25-22)16-8-12-19(13-9-16)28-18-4-2-1-3-5-18/h1-13H,14H2,(H,26,27)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	93	n/a	n/a	n/a	n/a	n/a	n/a
7TM Pharma A/S Curated by ChEMBL					Assay Description Displacement of[3H]PGD2 from human CRTH2 receptor expressed in HEK385-7 cells				Bioorg Med Chem Lett 20: 1181-5 (2010) Article DOI: 10.1016/j.bmcl.2009.12.015 BindingDB Entry DOI: 10.7270/Q2PR7W35
					More data for this Ligand-Target Pair