BDBM50310618 CHEMBL1078828::N-(2-(2-(6-(trifluoromethyl)-1H-benzo[d]imidazol-2-ylamino)thiazol-5-yl)ethyl)thieno[3,2-d]pyrimidin-4-amine

SMILES: FC(F)(F)c1ccc2nc(Nc3ncc(CCNc4ncnc5ccsc45)s3)[nH]c2c1

InChI Key: InChIKey=FNECROKREKHEJS-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50310618   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Aurora kinase A (Homo sapiens (Human))	BDBM50310618 (CHEMBL1078828 | N-(2-(2-(6-(trifluoromethyl)-1H-be...) Show SMILES FC(F)(F)c1ccc2nc(Nc3ncc(CCNc4ncnc5ccsc45)s3)[nH]c2c1 Show InChI InChI=1S/C19H14F3N7S2/c20-19(21,22)10-1-2-12-14(7-10)28-17(27-12)29-18-24-8-11(31-18)3-5-23-16-15-13(4-6-30-15)25-9-26-16/h1-2,4,6-9H,3,5H2,(H,23,25,26)(H2,24,27,28,29)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	490	n/a	n/a	n/a	n/a	n/a	n/a
Sunesis Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of Aurora A after 60 mins				Bioorg Med Chem Lett 19: 5158-61 (2009) Article DOI: 10.1016/j.bmcl.2009.07.016 BindingDB Entry DOI: 10.7270/Q2T72HK2
					More data for this Ligand-Target Pair
Aurora kinase B (Homo sapiens (Human))	BDBM50310618 (CHEMBL1078828 | N-(2-(2-(6-(trifluoromethyl)-1H-be...) Show SMILES FC(F)(F)c1ccc2nc(Nc3ncc(CCNc4ncnc5ccsc45)s3)[nH]c2c1 Show InChI InChI=1S/C19H14F3N7S2/c20-19(21,22)10-1-2-12-14(7-10)28-17(27-12)29-18-24-8-11(31-18)3-5-23-16-15-13(4-6-30-15)25-9-26-16/h1-2,4,6-9H,3,5H2,(H,23,25,26)(H2,24,27,28,29)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	620	n/a	n/a	n/a	n/a	n/a	n/a
Sunesis Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of Aurora B after 60 mins				Bioorg Med Chem Lett 19: 5158-61 (2009) Article DOI: 10.1016/j.bmcl.2009.07.016 BindingDB Entry DOI: 10.7270/Q2T72HK2
					More data for this Ligand-Target Pair