BDBM50311811 8-(4-(3-(2-chloro-3,6-difluorophenoxy)propyl)phenyl)-N-cyclopropyl-N-(3-methoxy-2-methylbenzyl)-5-azaspiro[2.5]oct-7-ene-7-carboxamide::CHEMBL1076448

SMILES: COc1cccc(CN(C2CC2)C(=O)C2=C(c3ccc(CCCOc4c(F)ccc(F)c4Cl)cc3)C3(CC3)CNC2)c1C

InChI Key: InChIKey=MWTQWVAUSOFVSS-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50311811   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Renin (Homo sapiens (Human))	BDBM50311811 (8-(4-(3-(2-chloro-3,6-difluorophenoxy)propyl)pheny...) Show SMILES COc1cccc(CN(C2CC2)C(=O)C2=C(c3ccc(CCCOc4c(F)ccc(F)c4Cl)cc3)C3(CC3)CNC2)c1C |c:15| Show InChI InChI=1S/C35H37ClF2N2O3/c1-22-25(6-3-7-30(22)42-2)20-40(26-12-13-26)34(41)27-19-39-21-35(16-17-35)31(27)24-10-8-23(9-11-24)5-4-18-43-33-29(38)15-14-28(37)32(33)36/h3,6-11,14-15,26,39H,4-5,12-13,16-21H2,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
Actelion Pharmaceuticals Ltd Curated by ChEMBL					Assay Description Inhibition of human rennin in human plasma assessed as accumulation of angiotensin 1 using human tetradecapeptide by immunoassay				Bioorg Med Chem Lett 19: 6762-5 (2009) Article DOI: 10.1016/j.bmcl.2009.09.104 BindingDB Entry DOI: 10.7270/Q23F4PRP
					More data for this Ligand-Target Pair
Renin (Homo sapiens (Human))	BDBM50311811 (8-(4-(3-(2-chloro-3,6-difluorophenoxy)propyl)pheny...) Show SMILES COc1cccc(CN(C2CC2)C(=O)C2=C(c3ccc(CCCOc4c(F)ccc(F)c4Cl)cc3)C3(CC3)CNC2)c1C |c:15| Show InChI InChI=1S/C35H37ClF2N2O3/c1-22-25(6-3-7-30(22)42-2)20-40(26-12-13-26)34(41)27-19-39-21-35(16-17-35)31(27)24-10-8-23(9-11-24)5-4-18-43-33-29(38)15-14-28(37)32(33)36/h3,6-11,14-15,26,39H,4-5,12-13,16-21H2,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	210	n/a	n/a	n/a	n/a	n/a	n/a
Actelion Pharmaceuticals Ltd Curated by ChEMBL					Assay Description Inhibition of human rennin in buffer assessed as accumulation of angiotensin 1 using human tetradecapeptide by immunoassay				Bioorg Med Chem Lett 19: 6762-5 (2009) Article DOI: 10.1016/j.bmcl.2009.09.104 BindingDB Entry DOI: 10.7270/Q23F4PRP
					More data for this Ligand-Target Pair