BDBM50313859 (R)-5-chloro-1-(1-cyclopropylethyl)-3-(6-ethoxy-2,5-dimethylpyridin-3-ylamino)pyrazin-2(1H)-one::CHEMBL1077249

SMILES: CCOc1nc(C)c(Nc2nc(Cl)cn([C@H](C)C3CC3)c2=O)cc1C

InChI Key: InChIKey=SXWMDGBWAMZSGN-GFCCVEGCSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50313859   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Corticotropin releasing factor receptor (Rattus norvegicus (rat))	BDBM50313859 ((R)-5-chloro-1-(1-cyclopropylethyl)-3-(6-ethoxy-2,...) Show SMILES CCOc1nc(C)c(Nc2nc(Cl)cn([C@H](C)C3CC3)c2=O)cc1C |r| Show InChI InChI=1S/C18H23ClN4O2/c1-5-25-17-10(2)8-14(11(3)20-17)21-16-18(24)23(9-15(19)22-16)12(4)13-6-7-13/h8-9,12-13H,5-7H2,1-4H3,(H,21,22)/t12-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.70	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company Curated by ChEMBL					Assay Description Displacement of [125I]Tyr-ovine-CRF from CRF1 receptor in rat frontal cortex homogenate by gamma counting				Bioorg Med Chem Lett 20: 1890-4 (2010) Article DOI: 10.1016/j.bmcl.2010.01.129 BindingDB Entry DOI: 10.7270/Q29G5MZ4
					More data for this Ligand-Target Pair