BDBM50314662 3-amino-2-(4-(3-(2-chloro-3,6-difluorophenoxy)propyl)benzyl)-N-cyclopropyl-N-(2,3-dichlorobenzyl)-2-methylpropanamide::CHEMBL1091852
SMILES: CC(CN)(Cc1ccc(CCCOc2c(F)ccc(F)c2Cl)cc1)C(=O)N(Cc1cccc(Cl)c1Cl)C1CC1
InChI Key: InChIKey=KBBHXCQPIMWCBS-UHFFFAOYSA-N
Data: 1 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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Renin (Homo sapiens (Human)) | BDBM50314662![]() (3-amino-2-(4-(3-(2-chloro-3,6-difluorophenoxy)prop...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 210 | n/a | n/a | n/a | n/a | 7.4 | n/a |
Merck Frosst Centre for Therapeutic Research Curated by ChEMBL | Assay Description Inhibition of human recombinant renin in PBS buffer at pH 7.4 | Bioorg Med Chem Lett 20: 2204-9 (2010) Article DOI: 10.1016/j.bmcl.2010.02.036 BindingDB Entry DOI: 10.7270/Q2W37WGD | |||||||||||
More data for this Ligand-Target Pair |