BDBM50315761 1-(4-{[4-(Dimethylamino)piperidin-1-yl]carbonyl}phenyl)-3-{4-[4-morpholin-4-yl-7-(2,2,2-trifluoroethyl)-7H-pyrrolo[2,3-d]-pyrimidin-2-yl]phenyl}urea::CHEMBL1092401

SMILES: CN(C)C1CCN(CC1)C(=O)c1ccc(NC(=O)Nc2ccc(cc2)-c2nc(N3CCOCC3)c3ccn(CC(F)(F)F)c3n2)cc1

InChI Key: InChIKey=QRQHRPXNUZROOQ-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50315761   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase mTOR (Homo sapiens (Human))	BDBM50315761 (1-(4-{[4-(Dimethylamino)piperidin-1-yl]carbonyl}ph...) Show SMILES CN(C)C1CCN(CC1)C(=O)c1ccc(NC(=O)Nc2ccc(cc2)-c2nc(N3CCOCC3)c3ccn(CC(F)(F)F)c3n2)cc1 Show InChI InChI=1S/C33H37F3N8O3/c1-41(2)26-11-14-43(15-12-26)31(45)23-5-9-25(10-6-23)38-32(46)37-24-7-3-22(4-8-24)28-39-29(42-17-19-47-20-18-42)27-13-16-44(30(27)40-28)21-33(34,35)36/h3-10,13,16,26H,11-12,14-15,17-21H2,1-2H3,(H2,37,38,46)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.70	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Inhibition of mTOR by DELFIA				J Med Chem 53: 3169-82 (2010) Article DOI: 10.1021/jm901783v BindingDB Entry DOI: 10.7270/Q21J99XP
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM50315761 (1-(4-{[4-(Dimethylamino)piperidin-1-yl]carbonyl}ph...) Show SMILES CN(C)C1CCN(CC1)C(=O)c1ccc(NC(=O)Nc2ccc(cc2)-c2nc(N3CCOCC3)c3ccn(CC(F)(F)F)c3n2)cc1 Show InChI InChI=1S/C33H37F3N8O3/c1-41(2)26-11-14-43(15-12-26)31(45)23-5-9-25(10-6-23)38-32(46)37-24-7-3-22(4-8-24)28-39-29(42-17-19-47-20-18-42)27-13-16-44(30(27)40-28)21-33(34,35)36/h3-10,13,16,26H,11-12,14-15,17-21H2,1-2H3,(H2,37,38,46)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Inhibition of human PI3Kalpha by fluorescence polarization format assay				J Med Chem 53: 3169-82 (2010) Article DOI: 10.1021/jm901783v BindingDB Entry DOI: 10.7270/Q21J99XP
					More data for this Ligand-Target Pair