BDBM50316354 2-[5-({(2R)-2-Amino-3-[3-(trifluoromethyl)phenyl]propyl}oxy)pyridin-3-yl]-8,9-dimethoxybenzo[c]-2,7-naphthyridin-4-amine::CHEMBL1095285

SMILES: COc1cc2ncc3c(N)nc(cc3c2cc1OC)-c1cncc(OC[C@H](N)Cc2cccc(c2)C(F)(F)F)c1

InChI Key: InChIKey=WEKPBIWDHVJAHJ-LJQANCHMSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50316354   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
3-phosphoinositide dependent protein kinase-1 (Homo sapiens (Human))	BDBM50316354 (2-[5-({(2R)-2-Amino-3-[3-(trifluoromethyl)phenyl]p...) Show SMILES COc1cc2ncc3c(N)nc(cc3c2cc1OC)-c1cncc(OC[C@H](N)Cc2cccc(c2)C(F)(F)F)c1 |r| Show InChI InChI=1S/C29H26F3N5O3/c1-38-26-10-22-21-9-24(37-28(34)23(21)14-36-25(22)11-27(26)39-2)17-8-20(13-35-12-17)40-15-19(33)7-16-4-3-5-18(6-16)29(30,31)32/h3-6,8-14,19H,7,15,33H2,1-2H3,(H2,34,37)/t19-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	21	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Inhibition of human GST-tagged-PDK1 expressed in HEK293 cells				Eur J Med Chem 45: 1379-86 (2010) Article DOI: 10.1016/j.ejmech.2009.12.036 BindingDB Entry DOI: 10.7270/Q2HD7VT5
					More data for this Ligand-Target Pair
Ribosomal protein S6 kinase (P70S6K) (Homo sapiens (Human))	BDBM50316354 (2-[5-({(2R)-2-Amino-3-[3-(trifluoromethyl)phenyl]p...) Show SMILES COc1cc2ncc3c(N)nc(cc3c2cc1OC)-c1cncc(OC[C@H](N)Cc2cccc(c2)C(F)(F)F)c1 |r| Show InChI InChI=1S/C29H26F3N5O3/c1-38-26-10-22-21-9-24(37-28(34)23(21)14-36-25(22)11-27(26)39-2)17-8-20(13-35-12-17)40-15-19(33)7-16-4-3-5-18(6-16)29(30,31)32/h3-6,8-14,19H,7,15,33H2,1-2H3,(H2,34,37)/t19-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	763	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Inhibition of p70S6K				Eur J Med Chem 45: 1379-86 (2010) Article DOI: 10.1016/j.ejmech.2009.12.036 BindingDB Entry DOI: 10.7270/Q2HD7VT5
					More data for this Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human))	BDBM50316354 (2-[5-({(2R)-2-Amino-3-[3-(trifluoromethyl)phenyl]p...) Show SMILES COc1cc2ncc3c(N)nc(cc3c2cc1OC)-c1cncc(OC[C@H](N)Cc2cccc(c2)C(F)(F)F)c1 |r| Show InChI InChI=1S/C29H26F3N5O3/c1-38-26-10-22-21-9-24(37-28(34)23(21)14-36-25(22)11-27(26)39-2)17-8-20(13-35-12-17)40-15-19(33)7-16-4-3-5-18(6-16)29(30,31)32/h3-6,8-14,19H,7,15,33H2,1-2H3,(H2,34,37)/t19-/m1/s1	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	889	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Inhibition of AKT				Eur J Med Chem 45: 1379-86 (2010) Article DOI: 10.1016/j.ejmech.2009.12.036 BindingDB Entry DOI: 10.7270/Q2HD7VT5
					More data for this Ligand-Target Pair