BDBM50317627 4-(2-(2-carboxyethyl)-3-(6-(5-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-4'-fluorobiphenyl-3-yloxy)hexyl)phenoxy)butanoic acid::CHEMBL1094350
SMILES: OC(=O)CCCOc1cccc(CCCCCCOc2cc(cc(c2)-c2ccc3OCCOc3c2)-c2ccc(F)cc2)c1CCC(O)=O
InChI Key: InChIKey=UFUBKPHWMFMDPY-UHFFFAOYSA-N
Data: 1 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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Leukotriene B4 receptor 1 (Homo sapiens (Human)) | BDBM50317627 (4-(2-(2-carboxyethyl)-3-(6-(5-(2,3-dihydrobenzo[b]...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 60.2 | n/a | n/a | n/a | n/a | n/a | n/a |
Roche Research Center Curated by ChEMBL | Assay Description Antagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 mins | J Med Chem 53: 3502-16 (2010) Article DOI: 10.1021/jm1001919 BindingDB Entry DOI: 10.7270/Q2KW5G67 | |||||||||||
More data for this Ligand-Target Pair |