BDBM50319046 (2S,3R,4R,5S,6R)-2-(4-chloro-3-((6-(cyclohexyloxy)pyridazin-3-yl)methyl)phenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol::CHEMBL1085770::US8541380, 59
SMILES: OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(Cl)c(Cc2ccc(OC3CCCCC3)nn2)c1
InChI Key: InChIKey=NXYQQUDNFQYLFU-IFPLKCGESA-N
Data: 2 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sodium/glucose cotransporter 2 (Homo sapiens (Human)) | BDBM50319046 ((2S,3R,4R,5S,6R)-2-(4-chloro-3-((6-(cyclohexyloxy)...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 111 | n/a | n/a | n/a | n/a | n/a | n/a |
Green Cross Corporation Curated by ChEMBL | Assay Description Inhibition of human SGLT2 expressed in CHO cells assessed as [14C]-alpha-methyl-D-glucopyranoside uptake after 2 hrs by liquid scintillation counting | Bioorg Med Chem Lett 20: 3420-5 (2010) Article DOI: 10.1016/j.bmcl.2010.04.006 BindingDB Entry DOI: 10.7270/Q24J0F8B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium/glucose cotransporter 2 (Homo sapiens (Human)) | BDBM50319046 ((2S,3R,4R,5S,6R)-2-(4-chloro-3-((6-(cyclohexyloxy)...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 111 | n/a | n/a | n/a | n/a | n/a | n/a |
Green Cross Corporation US Patent | Assay Description Inhibition assay using hSGLT2. | US Patent US8541380 (2013) BindingDB Entry DOI: 10.7270/Q2T43RQ3 | |||||||||||
More data for this Ligand-Target Pair |