BDBM50319070 (2S,3R,4R,5S,6R)-2-(3-((6-(1,3,4-thiadiazol-2-yl)pyridazin-3-yl)methyl)-4-chlorophenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol::CHEMBL1083975::US8541380, 46

SMILES: OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(Cl)c(Cc2ccc(nn2)-c2nncs2)c1

InChI Key: InChIKey=CKAIEVAUHBWSFT-SFFUCWETSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50319070   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Sodium/glucose cotransporter 2 (Homo sapiens (Human))	BDBM50319070 ((2S,3R,4R,5S,6R)-2-(3-((6-(1,3,4-thiadiazol-2-yl)p...) Show SMILES OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(Cl)c(Cc2ccc(nn2)-c2nncs2)c1 |r| Show InChI InChI=1S/C19H19ClN4O5S/c20-12-3-1-9(18-17(28)16(27)15(26)14(7-25)29-18)5-10(12)6-11-2-4-13(23-22-11)19-24-21-8-30-19/h1-5,8,14-18,25-28H,6-7H2/t14-,15-,16+,17-,18+/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	11.4	n/a	n/a	n/a	n/a	n/a	n/a
Green Cross Corporation Curated by ChEMBL					Assay Description Inhibition of human SGLT2 expressed in CHO cells assessed as [14C]-alpha-methyl-D-glucopyranoside uptake after 2 hrs by liquid scintillation counting				Bioorg Med Chem Lett 20: 3420-5 (2010) Article DOI: 10.1016/j.bmcl.2010.04.006 BindingDB Entry DOI: 10.7270/Q24J0F8B
					More data for this Ligand-Target Pair
Sodium/glucose cotransporter 2 (Homo sapiens (Human))	BDBM50319070 ((2S,3R,4R,5S,6R)-2-(3-((6-(1,3,4-thiadiazol-2-yl)p...) Show SMILES OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(Cl)c(Cc2ccc(nn2)-c2nncs2)c1 |r| Show InChI InChI=1S/C19H19ClN4O5S/c20-12-3-1-9(18-17(28)16(27)15(26)14(7-25)29-18)5-10(12)6-11-2-4-13(23-22-11)19-24-21-8-30-19/h1-5,8,14-18,25-28H,6-7H2/t14-,15-,16+,17-,18+/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	US Patent	n/a	n/a	11.4	n/a	n/a	n/a	n/a	n/a	n/a
Green Cross Corporation US Patent					Assay Description Inhibition assay using hSGLT2.				US Patent US8541380 (2013) BindingDB Entry DOI: 10.7270/Q2T43RQ3
					More data for this Ligand-Target Pair