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SMILES: CN1CC2(CCN(CC2)C(=O)Nc2cc(F)cc(F)c2)C1c1ccc(Cl)cc1

InChI Key: InChIKey=TWBFKHGAPSZHPL-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50322952   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Voltage-dependent T-type calcium channel subunit alpha-1H


(Homo sapiens (Human))		BDBM50322952
PNG
(1-(4-chlorophenyl)-N-(3,5-difluorophenyl)-2-methyl...)
Show SMILES CN1CC2(CCN(CC2)C(=O)Nc2cc(F)cc(F)c2)C1c1ccc(Cl)cc1
Show InChI InChI=1S/C21H22ClF2N3O/c1-26-13-21(19(26)14-2-4-15(22)5-3-14)6-8-27(9-7-21)20(28)25-18-11-16(23)10-17(24)12-18/h2-5,10-12,19H,6-9,13H2,1H3,(H,25,28)
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n/an/a 214n/an/an/an/an/an/a



Merck Research Laboratory

Curated by ChEMBL


Assay Description
Inhibition of human CaV3.2 expressed in HEK293 cells at -100 mV membrane potential by Ionworks HT assay

Bioorg Med Chem Lett 20: 4602-6 (2010)


Article DOI: 10.1016/j.bmcl.2010.06.012
BindingDB Entry DOI: 10.7270/Q2NS0V34
More data for this
Ligand-Target Pair