BDBM50323264 6-(4-ethoxy-3-(trifluoromethyl)phenyl)-1-(2-morpholinoethyl)-1H-imidazo[4,5-c]pyridine-4-carbonitrile::CHEMBL1208848

SMILES: CCOc1ccc(cc1C(F)(F)F)-c1cc2n(CCN3CCOCC3)cnc2c(n1)C#N

InChI Key: InChIKey=IAWRDJJFHSITBE-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50323264   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Cathepsin S (Homo sapiens (Human))	BDBM50323264 (6-(4-ethoxy-3-(trifluoromethyl)phenyl)-1-(2-morpho...) Show SMILES CCOc1ccc(cc1C(F)(F)F)-c1cc2n(CCN3CCOCC3)cnc2c(n1)C#N Show InChI InChI=1S/C22H22F3N5O2/c1-2-32-20-4-3-15(11-16(20)22(23,24)25)17-12-19-21(18(13-26)28-17)27-14-30(19)6-5-29-7-9-31-10-8-29/h3-4,11-12,14H,2,5-10H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of cathepsin S-mediated proteolytic cleavage of MHC2 associated invariant chain in human JY cells assessed as accumulation of lip10 by Wes...				Bioorg Med Chem Lett 20: 4350-4 (2010) Article DOI: 10.1016/j.bmcl.2010.06.072 BindingDB Entry DOI: 10.7270/Q2028RR9
					More data for this Ligand-Target Pair
Cathepsin S (Homo sapiens (Human))	BDBM50323264 (6-(4-ethoxy-3-(trifluoromethyl)phenyl)-1-(2-morpho...) Show SMILES CCOc1ccc(cc1C(F)(F)F)-c1cc2n(CCN3CCOCC3)cnc2c(n1)C#N Show InChI InChI=1S/C22H22F3N5O2/c1-2-32-20-4-3-15(11-16(20)22(23,24)25)17-12-19-21(18(13-26)28-17)27-14-30(19)6-5-29-7-9-31-10-8-29/h3-4,11-12,14H,2,5-10H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	37	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of human cathepsin S by fluorescence assay				Bioorg Med Chem Lett 20: 4350-4 (2010) Article DOI: 10.1016/j.bmcl.2010.06.072 BindingDB Entry DOI: 10.7270/Q2028RR9
					More data for this Ligand-Target Pair
Cathepsin K (Homo sapiens (Human))	BDBM50323264 (6-(4-ethoxy-3-(trifluoromethyl)phenyl)-1-(2-morpho...) Show SMILES CCOc1ccc(cc1C(F)(F)F)-c1cc2n(CCN3CCOCC3)cnc2c(n1)C#N Show InChI InChI=1S/C22H22F3N5O2/c1-2-32-20-4-3-15(11-16(20)22(23,24)25)17-12-19-21(18(13-26)28-17)27-14-30(19)6-5-29-7-9-31-10-8-29/h3-4,11-12,14H,2,5-10H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.66E+3	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of human cathepsin K by fluorescence assay				Bioorg Med Chem Lett 20: 4350-4 (2010) Article DOI: 10.1016/j.bmcl.2010.06.072 BindingDB Entry DOI: 10.7270/Q2028RR9
					More data for this Ligand-Target Pair