BindingDB logo
myBDB logout

null

SMILES: Fc1cc(Cl)cc(NC(=O)c2cc(F)cc(c2)C#N)c1

InChI Key: InChIKey=CCKMNZHOFWDNHD-UHFFFAOYSA-N

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50323315   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Metabotropic glutamate receptor 5


(Rattus norvegicus (Rat))		BDBM50323315
PNG
(CHEMBL1209620 | N-(3-chloro-5-fluorophenyl)-3-cyan...)
Show SMILES Fc1cc(Cl)cc(NC(=O)c2cc(F)cc(c2)C#N)c1
Show InChI InChI=1S/C14H7ClF2N2O/c15-10-4-12(17)6-13(5-10)19-14(20)9-1-8(7-18)2-11(16)3-9/h1-6H,(H,19,20)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 1.83E+3n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Antagonist activity at rat mGlu5 receptor expressed in HEK293A cells assessed as inhibition of glutamate-induced calcium mobilization

Bioorg Med Chem Lett 20: 4390-4 (2010)


Article DOI: 10.1016/j.bmcl.2010.06.064
BindingDB Entry DOI: 10.7270/Q2V9888D
More data for this
Ligand-Target Pair