BDBM50323375 CHEMBL1209400::c1,2-dicyclohexyl-3-(1H-pyrrol-3-yl)propan-1-one O-3-chlorophenylcarbamoyl oxime
SMILES: Clc1cccc(NC(=O)O\N=C(\C(Cc2cc[nH]c2)C2CCCCC2)C2CCCCC2)c1
InChI Key: InChIKey=HAXDBZSPUNQHFS-QCWLDUFUSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat)) | BDBM50323375![]() (CHEMBL1209400 | c1,2-dicyclohexyl-3-(1H-pyrrol-3-y...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 16 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Gedeon Richter Plc Curated by ChEMBL | Assay Description Displacement of [3H]-M-MPEP from rat mGLUR5 | Bioorg Med Chem Lett 20: 4371-5 (2010) Article DOI: 10.1016/j.bmcl.2010.06.075 BindingDB Entry DOI: 10.7270/Q2G1611F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat)) | BDBM50323375![]() (CHEMBL1209400 | c1,2-dicyclohexyl-3-(1H-pyrrol-3-y...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 194 | n/a | n/a | n/a | n/a | n/a | n/a |
Gedeon Richter Plc Curated by ChEMBL | Assay Description Antagonist activity at mGLUR5 in rat E17 cells assessed as calcium accumulation by fluorimetry | Bioorg Med Chem Lett 20: 4371-5 (2010) Article DOI: 10.1016/j.bmcl.2010.06.075 BindingDB Entry DOI: 10.7270/Q2G1611F | |||||||||||
More data for this Ligand-Target Pair |