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SMILES: COc1cccc(NC(=O)O\N=C(\C(Cc2cccs2)C2CCCCC2)C2CCCCC2)c1

InChI Key: InChIKey=DEQQPMOLBTYQDJ-PBBVDAKRSA-N

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   Substructure
Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50323381   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Metabotropic glutamate receptor 5


(Rattus norvegicus (Rat))
BDBM50323381
PNG
((1,2-dicyclohexyl-3-(6-thioxocyclohexa-1,3-dienyl)...)
Show SMILES COc1cccc(NC(=O)O\N=C(\C(Cc2cccs2)C2CCCCC2)C2CCCCC2)c1
Show InChI InChI=1S/C27H36N2O3S/c1-31-23-15-8-14-22(18-23)28-27(30)32-29-26(21-12-6-3-7-13-21)25(19-24-16-9-17-33-24)20-10-4-2-5-11-20/h8-9,14-18,20-21,25H,2-7,10-13,19H2,1H3,(H,28,30)/b29-26+
PDB
MMDB

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CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
88n/an/an/an/an/an/an/an/a



Gedeon Richter Plc

Curated by ChEMBL


Assay Description
Displacement of [3H]-M-MPEP from rat mGLUR5


Bioorg Med Chem Lett 20: 4371-5 (2010)


Article DOI: 10.1016/j.bmcl.2010.06.075
BindingDB Entry DOI: 10.7270/Q2G1611F
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Rattus norvegicus (Rat))
BDBM50323381
PNG
((1,2-dicyclohexyl-3-(6-thioxocyclohexa-1,3-dienyl)...)
Show SMILES COc1cccc(NC(=O)O\N=C(\C(Cc2cccs2)C2CCCCC2)C2CCCCC2)c1
Show InChI InChI=1S/C27H36N2O3S/c1-31-23-15-8-14-22(18-23)28-27(30)32-29-26(21-12-6-3-7-13-21)25(19-24-16-9-17-33-24)20-10-4-2-5-11-20/h8-9,14-18,20-21,25H,2-7,10-13,19H2,1H3,(H,28,30)/b29-26+
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 181n/an/an/an/an/an/a



Gedeon Richter Plc

Curated by ChEMBL


Assay Description
Antagonist activity at mGLUR5 in rat E17 cells assessed as calcium accumulation by fluorimetry


Bioorg Med Chem Lett 20: 4371-5 (2010)


Article DOI: 10.1016/j.bmcl.2010.06.075
BindingDB Entry DOI: 10.7270/Q2G1611F
More data for this
Ligand-Target Pair