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SMILES: O=C(Nc1ccccc1)O\N=C(\C(CN1CCN(CC1)c1ccccc1)C1CCCCC1)C1CCCCC1

InChI Key: InChIKey=YHXBBZHFFUJFHR-WUVHBKSUSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50323383   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Metabotropic glutamate receptor 5


(Rattus norvegicus (Rat))		BDBM50323383
PNG
(1,2-dicyclohexyl-3-(4-phenylpiperazin-1-yl)propan-...)
Show SMILES O=C(Nc1ccccc1)O\N=C(\C(CN1CCN(CC1)c1ccccc1)C1CCCCC1)C1CCCCC1
Show InChI InChI=1S/C32H44N4O2/c37-32(33-28-17-9-3-10-18-28)38-34-31(27-15-7-2-8-16-27)30(26-13-5-1-6-14-26)25-35-21-23-36(24-22-35)29-19-11-4-12-20-29/h3-4,9-12,17-20,26-27,30H,1-2,5-8,13-16,21-25H2,(H,33,37)/b34-31+
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PC cid
PC sid
UniChem
Article
PubMed
>1.00E+3n/an/an/an/an/an/an/an/a



Gedeon Richter Plc

Curated by ChEMBL


Assay Description
Antagonist activity at mGLUR5 in rat E17 cells assessed as calcium accumulation by fluorimetry

Bioorg Med Chem Lett 20: 4371-5 (2010)


Article DOI: 10.1016/j.bmcl.2010.06.075
BindingDB Entry DOI: 10.7270/Q2G1611F
More data for this
Ligand-Target Pair