BDBM50323899 1,1,1-trifluoro-N-(3-(((3S,4R)-4-(hydroxymethyl)-2,2-dimethyl-7-(2-(6-methylquinolin-2-yl)vinyl)chroman-3-yl)methyl)-4-methoxyphenyl)methanesulfonamide::CHEMBL1214532
SMILES: COc1ccc(NS(=O)(=O)C(F)(F)F)cc1C[C@H]1[C@@H](CO)c2cc(\C=C\c3ccc4ccc(C)cc4n3)ccc2OC1(C)C
InChI Key: InChIKey=SSDUBZIKJQBPNW-VIYFAYNESA-N
Data: 1 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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Cysteinyl leukotriene receptor (Homo sapiens (Human)) | BDBM50323899 (1,1,1-trifluoro-N-(3-(((3S,4R)-4-(hydroxymethyl)-2...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
Zhejiang University Curated by ChEMBL | Assay Description Antagonist activity at CysLT1 receptor in human dU937 cells assessed as inhibition of LTD4-induced increase of calcium level treated 30 mins before L... | Bioorg Med Chem 18: 5519-27 (2010) Article DOI: 10.1016/j.bmc.2010.06.047 BindingDB Entry DOI: 10.7270/Q26D5TZ0 | |||||||||||
More data for this Ligand-Target Pair |