BDBM50324452 (E)-4-(6-Iodo-4-oxo-2-(2-(pyridin-3-yl)vinyl)quinazolin-3(4H)-yl)benzoic Acid::CHEMBL1214940

SMILES: OC(=O)c1ccc(cc1)-n1c(\C=C\c2cccnc2)nc2ccc(I)cc2c1=O

InChI Key: InChIKey=KFRHIFMJBBRWCK-XCVCLJGOSA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50324452   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Glutamate [NMDA] receptor subunit epsilon 3/zeta 1 (RAT-Rattus norvegicus (Rat))	BDBM50324452 ((E)-4-(6-Iodo-4-oxo-2-(2-(pyridin-3-yl)vinyl)quina...) Show SMILES OC(=O)c1ccc(cc1)-n1c(\C=C\c2cccnc2)nc2ccc(I)cc2c1=O Show InChI InChI=1S/C22H14IN3O3/c23-16-6-9-19-18(12-16)21(27)26(17-7-4-15(5-8-17)22(28)29)20(25-19)10-3-14-2-1-11-24-13-14/h1-13H,(H,28,29)/b10-3+	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Emory University Curated by ChEMBL					Assay Description Antagonist activity at rat recombinant NR1-NR2C receptor expressed in Xenopus oocytes at holding potential of -40mV by two-electrode voltage-clamp el...				J Med Chem 53: 5476-90 (2010) Article DOI: 10.1021/jm100027p BindingDB Entry DOI: 10.7270/Q2DR2VQF
					More data for this Ligand-Target Pair
Glutamate [NMDA] receptor subunit epsilon 2/zeta 1 (Rattus norvegicus (Rat)-RAT)	BDBM50324452 ((E)-4-(6-Iodo-4-oxo-2-(2-(pyridin-3-yl)vinyl)quina...) Show SMILES OC(=O)c1ccc(cc1)-n1c(\C=C\c2cccnc2)nc2ccc(I)cc2c1=O Show InChI InChI=1S/C22H14IN3O3/c23-16-6-9-19-18(12-16)21(27)26(17-7-4-15(5-8-17)22(28)29)20(25-19)10-3-14-2-1-11-24-13-14/h1-13H,(H,28,29)/b10-3+	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.10E+4	n/a	n/a	n/a	n/a	n/a	n/a
Emory University Curated by ChEMBL					Assay Description Antagonist activity at rat recombinant NR1-NR2B receptor expressed in Xenopus oocytes at holding potential of -40mV by two-electrode voltage-clamp el...				J Med Chem 53: 5476-90 (2010) Article DOI: 10.1021/jm100027p BindingDB Entry DOI: 10.7270/Q2DR2VQF
					More data for this Ligand-Target Pair
Glutamate [NMDA] receptor subunit epsilon 1/zeta 1 (Rattus norvegicus (Rat)-RAT)	BDBM50324452 ((E)-4-(6-Iodo-4-oxo-2-(2-(pyridin-3-yl)vinyl)quina...) Show SMILES OC(=O)c1ccc(cc1)-n1c(\C=C\c2cccnc2)nc2ccc(I)cc2c1=O Show InChI InChI=1S/C22H14IN3O3/c23-16-6-9-19-18(12-16)21(27)26(17-7-4-15(5-8-17)22(28)29)20(25-19)10-3-14-2-1-11-24-13-14/h1-13H,(H,28,29)/b10-3+	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.60E+4	n/a	n/a	n/a	n/a	n/a	n/a
Emory University Curated by ChEMBL					Assay Description Antagonist activity at rat recombinant NR1-NR2A receptor expressed in Xenopus oocytes at holding potential of -40mV by two-electrode voltage-clamp el...				J Med Chem 53: 5476-90 (2010) Article DOI: 10.1021/jm100027p BindingDB Entry DOI: 10.7270/Q2DR2VQF
					More data for this Ligand-Target Pair
Glutamate receptor 1 (Rattus norvegicus (Rat))	BDBM50324452 ((E)-4-(6-Iodo-4-oxo-2-(2-(pyridin-3-yl)vinyl)quina...) Show SMILES OC(=O)c1ccc(cc1)-n1c(\C=C\c2cccnc2)nc2ccc(I)cc2c1=O Show InChI InChI=1S/C22H14IN3O3/c23-16-6-9-19-18(12-16)21(27)26(17-7-4-15(5-8-17)22(28)29)20(25-19)10-3-14-2-1-11-24-13-14/h1-13H,(H,28,29)/b10-3+	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6.10E+4	n/a	n/a	n/a	n/a	n/a	n/a
Emory University Curated by ChEMBL					Assay Description Antagonist activity at rat recombinant GLuR1 expressed in Xenopus oocytes assessed as inhibition of glutamate-induced current by two-electrode voltag...				J Med Chem 53: 5476-90 (2010) Article DOI: 10.1021/jm100027p BindingDB Entry DOI: 10.7270/Q2DR2VQF
					More data for this Ligand-Target Pair